Evidence map›Paper›PMID 36567455›Full record

ReviewIntegrative cancer therapies

Traditional Herbal Medicine: A Potential Therapeutic Approach for Adjuvant Treatment of Non-small Cell Lung Cancer in the Future.

Jie Huang, Jia-Xin Li, Lin-Rui Ma, Dong-Han Xu, Peng Wang, Li-Qi Li, Li-Li Yu, Yu Li, Run-Ze Li, Hao Zhang and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Vismodegib-loaded ufasomes inhaler for treatment of non-small cell lung cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  3. International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Development of topical silver nano gel formulation of Bixin: Characterization, and evaluation of anticancer activity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jie HuangMacau University of Science and Technology, Taipa, Macau, China.ORCID 0000-0003-2782-2453
Jia-Xin LiMacau University of Science and Technology, Taipa, Macau, China.ORCID 0000-0002-7489-8840
Lin-Rui MaMacau University of Science and Technology, Taipa, Macau, China.
Dong-Han XuMacau University of Science and Technology, Taipa, Macau, China.
Peng WangMacau University of Science and Technology, Taipa, Macau, China.
Li-Qi LiMacau University of Science and Technology, Taipa, Macau, China.
Li-Li YuMacau University of Science and Technology, Taipa, Macau, China.
Yu LiMacau University of Science and Technology, Taipa, Macau, China.
Run-Ze LiSecond Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Hao ZhangMacau University of Science and Technology, Taipa, Macau, China.
Yu-Hong ZhengMacau University of Science and Technology, Taipa, Macau, China.
Ling TangSouthern Medical University, Guangzhou, Guangdong, China.
Pei-Yu YanMacau University of Science and Technology, Taipa, Macau, China.
Macau University of Science and Technology · MOGuangzhou University of Chinese Medicine · CNKey Laboratory of Guangdong Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung carcinoma is the primary reason for cancer-associated mortality, and it exhibits the highest mortality and incidence in developed and developing countries. Non-small cell lung cancer (NSCLC) and SCLC are the 2 main types of lung cancer, with NSCLC contributing to 85% of all lung carcinoma cases. Conventional treatment mainly involves surgery, chemoradiotherapy, and immunotherapy, but has a dismal prognosis for many patients. Therefore, identifying an effective adjuvant therapy is urgent. Historically, traditional herbal medicine has been an essential part of complementary and alternative medicine, due to its numerous targets, few side effects and substantial therapeutic benefits. In China and other East Asian countries, traditional herbal medicine is increasingly popular, and is highly accepted by patients as a clinical adjuvant therapy. Numerous studies have reported that herbal extracts and prescription medications are effective at combating tumors. It emphasizes that, by mainly regulating the P13K/AKT signaling pathway, the Wnt signaling pathway, and the NF-κB signaling pathway, herbal medicine induces apoptosis and inhibits the proliferation and migration of tumor cells. The present review discusses the anti-NSCLC mechanisms of herbal medicines and provides options for future adjuvant therapy in patients with NSCLC.

Indexed as

CarcinomaCarcinoma, Non-Small-Cell LungDrugs, Chinese HerbalLung NeoplasmsPlants, MedicinalCell Line, TumorHerbal MedicineHumansWnt Signaling PathwayDrugs, Chinese Herbaladjuvant treatmentherbal medicinenon-small cell lung cancertraditional Chinese medicine

Identifiers

PMID36567455
PMCPMC9806388
OpenAlexW4312719650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.