Evidence map›Paper›PMID 36567375›Full record

ArticleFolia microbiologica2023

Comparative genomics of trimethoprim-sulfamethoxazole-resistant Achromobacter xylosoxidans clinical isolates from Serbia reveals shortened variant of class 1 integron integrase gene.

Brankica Filipić, Milka Malešević, Zorica Vasiljević, Katarina Novović, Milan Kojić, Branko Jovčić

Abstract read
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In one paragraph

Article in Folia microbiologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Brankica FilipićFaculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Milka MaleševićInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Zorica VasiljevićInstitute for Mother and Child Health Care, Belgrade, Serbia.
Katarina NovovićInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Milan KojićInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Branko JovčićInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia. bjovcic@bio.bg.ac.rs.ORCID http://orcid.org/0000-0002-9500-3786
University of Belgrade · RSInstitute of Public Health of Serbia · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-68/2022-14/200042Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-68/2022-14/200161Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-68/2022-14/200178
6 · The paper itself

Abstract

Trimethoprim-sulfamethoxazole (SXT) is the preferable treatment option of the infections caused by Achromobacter spp. Our study aimed to analyze the SXT resistance of 98 Achromobacter spp. isolates from pediatric patients, among which 33 isolates were SXT-resistant. The presence of intI1 was screened by PCR and genome sequence analyses. The intI1 gene was detected in 10 of SXT-resistant isolates that had shorter intI1 PCR fragments named intI1S. Structural changes in intI1S were confirmed by genome sequencing and analyses which revealed 86 amino acids deletion in IntI1S protein compared to canonical IntI1 protein. All IntI1S isolates were of non-CF origin. Pan-genome analysis of intI1S bearing A. xylosoxidans isolates comprised 9052 genes, with the core genome consisting of 5455 protein-coding genes. Results in this study indicate that IntI1S isolates were derived from clinical settings and that cystic fibrosis (CF) patients were potential reservoirs for healthcare-associated infections that occurred in non-CF patients.

Indexed as

AchromobacterAchromobacter denitrificansCystic FibrosisGram-Negative Bacterial InfectionsAnti-Bacterial AgentsChildGenomicsHumansIntegrasesIntegronsMicrobial Sensitivity TestsSerbiaTrimethoprim, Sulfamethoxazole Drug CombinationAnti-Bacterial AgentsIntegrasesTrimethoprim, Sulfamethoxazole Drug CombinationAchromobacter spp.Class 1 integron integraseGenome comparison

Identifiers

PMID36567375
OpenAlexW4312194768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.