Evidence map›Paper›PMID 36567329›Full record

ArticleJournal of cardiothoracic surgery2022

Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study.

George Vasquez-Rios, Dennis G Moledina, Yaqi Jia, Eric McArthur, Sherry G Mansour, Heather Thiessen-Philbrook, Michael G Shlipak, Jay L Koyner, Amit X Garg, Chirag R Parikh and 2 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. N -Acetyl-Tryptophan in Acute Kidney Injury after Cardiac Surgery.Journal of the American Society of Nephrology : JASN · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

George Vasquez-RiosDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1243, New York, NY, 10029, USA.
Dennis G MoledinaSection of Nephrology and Clinical and Translational Research Accelerator, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Yaqi JiaDivision of Nephrology, School of Medicine, Johns Hopkins University, 1830 E. Monument St., Suite 416, Baltimore, MD, 21287, USA.
Eric McArthurICES, Toronto, ON, Canada.
Sherry G MansourSection of Nephrology and Clinical and Translational Research Accelerator, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Heather Thiessen-PhilbrookDivision of Nephrology, School of Medicine, Johns Hopkins University, 1830 E. Monument St., Suite 416, Baltimore, MD, 21287, USA.
Michael G ShlipakKidney Health Research Collaborative, University of California San Francisco, San Francisco, CA, USA.
Jay L KoynerSection of Nephrology, Department of Medicine, Pritzker School of Medicine University of Chicago, Chicago, USA.
Amit X GargICES, Toronto, ON, Canada.
Chirag R ParikhDivision of Nephrology, School of Medicine, Johns Hopkins University, 1830 E. Monument St., Suite 416, Baltimore, MD, 21287, USA. Chirag.Parikh@jhmi.edu.
Steven G CocaDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1243, New York, NY, 10029, USA. steven.coca@mssm.edu.
TRIBE-AKI Consortium
Johns Hopkins University · USIcahn School of Medicine at Mount Sinai · USYale University · USSan Francisco VA Medical Center · USUniversity of Chicago · USWestern University · CA

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Identification of Non-Invasive Biomarkers and Indices for Diagnosis of Drug-Induced Acute Interstitial NephritisK23DK117065 · NIDDK · YALE UNIVERSITY · PI MOLEDINA, DENNIS G. · 2018 to 2022
$920k
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundSoluble tumor necrosis factor receptor (sTNFR)1, sTNFR2, and plasma kidney injury molecule-1 (KIM-1) are associated with kidney events in patients with and without diabetes. However, their associations with clinical outcomes when obtained pre-operatively have not been explored.

methodsThe TRIBE-AKI cohort study is a prospective, multicenter, cohort study of high-risk adults undergoing cardiac surgery. We assessed the associations between pre-operative concentrations of plasma sTNFR1, sTNFR2, and KIM-1 and post-operative long-term outcomes including mortality, cardiovascular events, and chronic kidney disease (CKD) incidence or progression after discharge.

resultsAmong 1378 participants included in the analysis with a median follow-up period of 6.7 (IQR 4.0-7.9) years, 434 (31%) patients died, 256 (19%) experienced cardiovascular events and out of 837 with available long-term kidney function data, 30% developed CKD. After adjustment for clinical covariates, each log increase in biomarker concentration was independently associated with mortality with 95% CI adjusted hazard ratios (aHRs) of 3.0 (2.3-4.0), 2.3 (1.8-2.9), and 2.0 (1.6-2.4) for sTNFR1, sTNFR2, and KIM-1, respectively. For cardiovascular events, the 95% CI aHRs were 2.1 (1.5-3.1), 1.9 (1.4-2.6) and 1.6 (1.2-2.1) for sTNFR1, sTNFR2 and KIM-1, respectively. For CKD events, the aHRs were 2.2 (1.5-3.1) for sTNFR1, 1.9 (1.3-2.7) for sTNFR2, and 1.7 (1.3-2.3) for KIM-1. Despite the associations, each of the biomarkers alone or in combination failed to result in robust discrimination on an absolute basis or compared to a clinical model.

conclusionsTNFR1, sTNFR2, and KIM-1 were independently associated with longitudinal outcomes after discharge from a cardiac surgery hospitalization including death, cardiovascular, and CKD events when obtained pre-operatively in high-risk individuals. Pre-operative plasma biomarkers could serve to assist during the evaluation of patients in whom cardiac surgery is planned.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresCardiovascular DiseasesRenal Insufficiency, ChronicAdultBiomarkersCohort StudiesHumansKidneyProspective StudiesBiomarkersAcute renal failureDeathInflammationPrognosis

Identifiers

PMID36567329
PMCPMC9790121
OpenAlexW4313198809

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.