Evidence map›Paper›PMID 36567126›Full record

ArticleThe Journal of reproduction and development2023

A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas.

Hiroshi Yomogita, Hikaru Ito, Kento Hashimoto, Akihiko Kudo, Toshiaki Fukushima, Tsutomu Endo, Yoshikazu Hirate, Yoshihiro Akimoto, Masayuki Komada, Yoshiakira Kanai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Hiroshi YomogitaDepartment of Perinatal and Women's Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Hikaru ItoCenter for Experimental Animals, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Kento HashimotoCenter for Experimental Animals, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Akihiko KudoDepartment of Microscopic Anatomy, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
Toshiaki FukushimaCell Biology Center, Tokyo Institute of Technology, Kanagawa 226-8503, Japan.
Tsutomu EndoCenter for Experimental Animals, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Yoshikazu HirateCenter for Experimental Animals, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Yoshihiro AkimotoDepartment of Microscopic Anatomy, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
Masayuki KomadaCell Biology Center, Tokyo Institute of Technology, Kanagawa 226-8503, Japan.
Yoshiakira KanaiDepartment of Veterinary Anatomy, University of Tokyo, Tokyo 113-8657, Japan.
Naoyuki MiyasakaDepartment of Perinatal and Women's Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Masami Kanai-AzumaCenter for Experimental Animals, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Tokyo Medical and Dental University · JPKanagawa Institute of Technology · JPKyorin University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mice and humans, Nik-related protein kinase (Nrk) is an X-linked gene that encodes a serine/threonine kinase belonging to GCK group 4. Nrk knockout (Nrk KO) mice exhibit delayed delivery, possibly due to defective communication between the Nrk KO conceptus and its mother. However, the mechanism of delayed labor remains largely unknown. Here, we found that in pregnant mothers with the Nrk KO conceptus, the serum progesterone (P4) and placental lactogen (PL-2) concentrations in late pregnancy were higher than those in the wild type. Moreover, we demonstrated that Nrk is expressed in trophoblast giant cells (TGCs) and syncytiotrophoblast-2 (SynT-2) in the labyrinth layer of the mouse placenta. In the human placenta, NRK is also expressed in Syn-T in villi. Both human Syn-T and mouse TGCs of the labyrinth layer are present within fetal tissues that are in direct contact with the maternal blood. The labyrinth layer of the Nrk KO conceptus was gigantic, with enlarged cytoplasm and Golgi bodies in the TGCs. To investigate the function of Nrk in the labyrinth layer, a differentially expressed gene (DEG) analysis was performed. The DEG analysis revealed that labor-promoting factors, such as prostaglandins, were decreased, and pregnancy-maintaining factors, such as the prolactin family and P4 receptor, were increased. These findings suggest that the Nrk KO mice exhibit delayed delivery owing to high P4 concentrations caused by the hypersecretion of pregnancy-maintaining factors, such as PL-2, from the placenta.

Indexed as

PlacentaProtein Serine-Threonine KinasesAnimalsFemaleHumansMiceMice, KnockoutPregnancyProlactinTrophoblastsProlactinProtein Serine-Threonine KinasesDelayed deliveryNik-related kinaseProgesteroneProlactinTrophoblast giant cells

Identifiers

PMID36567126
PMCPMC9939280
OpenAlexW4312196325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.