Evidence map›Paper›PMID 36567003›Full record

ArticleMathematical biosciences2023

A simple model for viral decay dynamics and the distribution of infected cell life spans in SHIV-infected infant rhesus macaques.

Julian Sass, Achal Awasthi, Veronica Obregon-Perko, Janice McCarthy, Alun L Lloyd, Ann Chahroudi, Sallie Permar, Cliburn Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mathematical biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julian SassDepartment of Mathematics, North Carolina State University, Raleigh, NC, USA. Electronic address: jasass@ncsu.edu.
Achal AwasthiDepartment of Bioinformatics and Biostatistics, Duke University, Durham, USA; Duke Center for Human Systems Immunology, Duke University, Durham, USA. Electronic address: achal.awasthi@duke.edu.
Veronica Obregon-PerkoDepartment of Pediatrics, Emory University, Atlanta, USA. Electronic address: veronica.a.obregon-perko@emory.edu.
Janice McCarthyDepartment of Bioinformatics and Biostatistics, Duke University, Durham, USA; Duke Center for Human Systems Immunology, Duke University, Durham, USA. Electronic address: janice.mccarthy@duke.edu.
Alun L LloydDepartment of Mathematics, North Carolina State University, Raleigh, NC, USA. Electronic address: alun_lloyd@ncsu.edu.
Ann ChahroudiDepartment of Pediatrics, Emory University, Atlanta, USA; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, USA.
Sallie PermarDepartment of Pediatrics, Weill Cornell Medicine, NY, USA.
Cliburn ChanDepartment of Bioinformatics and Biostatistics, Duke University, Durham, USA; Duke Center for Human Systems Immunology, Duke University, Durham, USA. Electronic address: cliburn.chan@duke.edu.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
The origin, predictors, and immune correlates of viral rebound in orally SHIV infected infant monkeysP01AI131276 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI PERMAR, SALLIE R. · 2017 to 2021
$8.3M
Immune interventions in SIV-infected ART-suppressed infant macaquesR01AI133706 · NIAID · EMORY UNIVERSITY · PI CHAHROUDI, ANN M · 2017 to 2021
$4.1M
Quantitative Methods for HIV/AIDS ResearchR25AI140495 · NIAID · DUKE UNIVERSITY · PI Cliburn C Chan, Gina-Maria Pomann · 2018 to 2026
$2.8M
NIAID NIH HHS P01 AI131276NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI133706NIAID NIH HHS R25 AI140495NIH HHS P51 OD011132
6 · The paper itself

Abstract

The dynamics of HIV viral load following the initiation of antiretroviral therapy is not well-described by simple, single-phase exponential decay. Several mathematical models have been proposed to describe its more complex behavior, the most popular of which is two-phase exponential decay. The underlying assumption in two-phase exponential decay is that there are two classes of infected cells with different lifespans. However, with the exception of CD4

Indexed as

HIV-1HIV InfectionsSimian Immunodeficiency VirusAnimalsLongevityMacaca mulattaViral LoadHIV viral decayInfected cell lifespanModified Gompertz modelSHIVStochastic modelingUncertainty quantification

Identifiers

PMID36567003
PMCPMC9918703

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.