Evidence map›Paper›PMID 36566697›Full record

ArticleESMO open2023

Impact of EGFR

A Noeuveglise, N Sarafan-Vasseur, L Beaussire, F Marguet, R Modzelewski, C Hanzen, C Alexandru, N Magne, O Langlois, F Di Fiore and 3 more

Open access · goldAbstract read
In one paragraph

Article in ESMO open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

A NoeuvegliseRadiotherapy Department, Henri Becquerel Cancer Center, Rouen.
N Sarafan-VasseurUniv Rouen Normandie, Inserm U1245, Cancer And Brain Genomics, Rouen.
L BeaussireUniv Rouen Normandie, Inserm U1245, Cancer And Brain Genomics, Rouen.
F MarguetUniv Rouen Normandie, Inserm U1245, Cancer And Brain Genomics, Rouen; Department of Pathology, Rouen University Hospital, Rouen.
R ModzelewskiNuclear Medicine Department, Henri Becquerel Center, Rouen.
C HanzenRadiotherapy Department, Henri Becquerel Cancer Center, Rouen.
C AlexandruDepartment of Medical Oncology, Cancer Centre Henri Becquerel, Rue d'Amiens, Rouen.
N MagneDepartment of Radiology, Rouen University Hospital, Rouen.
O LangloisDepartment of Neurosurgery, Rouen University Hospital, Rouen.
F Di FioreUniv Rouen Normandie, Inserm U1245, Cancer And Brain Genomics, Rouen; Department of Gastroenterology, Rouen University Hospital, Rouen.
F ClatotUniv Rouen Normandie, Inserm U1245, Cancer And Brain Genomics, Rouen; Department of Medical Oncology, Cancer Centre Henri Becquerel, Rue d'Amiens, Rouen.
S ThureauRadiotherapy Department, Henri Becquerel Cancer Center, Rouen; QuantIF-LITIS EA4108, University of Rouen, Rouen, France.
M FontanillesUniv Rouen Normandie, Inserm U1245, Cancer And Brain Genomics, Rouen; Department of Medical Oncology, Cancer Centre Henri Becquerel, Rue d'Amiens, Rouen. Electronic address: maxime.fontanilles@chb.unicancer.fr.
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers · FRCentre Hospitalier Universitaire de Rouen · FRUniversité de Rouen Normandie · FRGénomique du cancer et du cerveauInserm · FRLaboratoire National Henri Becquerel · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular factors influence relapse patterns in glioblastoma. The hotspot mutation located at position 289 of the extracellular domain of the epidermal growth factor receptor (EGFR PATIENTS AND

methodsAn ancillary study from a prospective cohort of patients suffering from glioblastoma was conducted. All patients received radiotherapy and concomitant temozolomide. The population was divided into two groups according to EGFR

resultsOne hundred twenty-eight patients were included and analyzed: 11% had EGFR

conclusionWe highlighted a link between the EGFR

Indexed as

GlioblastomaErbB ReceptorsHumansMutationProspective StudiesRecurrenceEGFR protein, humanErbB ReceptorsEGFRglioblastomamutationoverlap scoreradiotherapyrelapse pattern

Identifiers

PMID36566697
PMCPMC10024094
OpenAlexW4312194621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.