Evidence map›Paper›PMID 36566553›Full record

ArticleBiomaterials2023

Development and systematic characterization of GelMA/alginate/PEGDMA/xanthan gum hydrogel bioink system for extrusion bioprinting.

Jiannan Li, Seyedsina Moeinzadeh, Carolyn Kim, Chi-Chun Pan, George Weale, Sungwoo Kim, Geoffrey Abrams, Aaron W James, HyeRan Choo, Charles Chan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 50 citations in OpenAlex.

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  20. Production of Bacterial Exopolysaccharides: Xanthan and Bacterial Cellulose.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jiannan LiDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA.
Seyedsina MoeinzadehDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA.
Carolyn KimDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA; Department of Mechanical Engineering, Stanford University, 440 Escondido Mall, Stanford, CA94305, USA.
Chi-Chun PanDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA; Department of Mechanical Engineering, Stanford University, 440 Escondido Mall, Stanford, CA94305, USA.
George WealeDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA.
Sungwoo KimDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA.
Geoffrey AbramsDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, 720 Rutland Avenue, Room 524A, Baltimore, MD, 21205, USA.
HyeRan ChooDepartment of Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA94305, USA.
Charles ChanDepartment of Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA94305, USA.
Yunzhi Peter YangDepartment of Orthopaedic Surgery, Stanford University, 240 Pasteur Drive, Stanford, CA94304, USA; Department of Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA94305, USA; Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA94305, USA. Electronic address: ypyang@stanford.edu.
Stanford University · USJohns Hopkins University · US

Funding

Systems Modeling Guided Bone regenerationU01AR069395 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YANG, YUNZHI, ZHOU, XIAOBO · 2016 to 2021
$3.4M
Tissue Engineering Approaches for Improved Treatment of Early Stage Osteonecrosis of the HipR01AR072613 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B, YANG, YUNZHI · 2018 to 2022
$2.2M
Vascularization in bone tissue engineering constructsR01AR074458 · NIAMS · STANFORD UNIVERSITY · PI YANG, YUNZHI · 2019 to 2023
$1.7M
NIAMS NIH HHS R01 AR072613NIAMS NIH HHS R01 AR074458NIAMS NIH HHS U01 AR069395
6 · The paper itself

Abstract

Gelatin methacryloyl (GelMA)/alginate-based hydrogels have shown great promise in bioprinting, but their printability is limited at room temperature. In this paper, we present our development of a room temperature printable hydrogel bioink by introducing polyethylene glycol dimethacrylate (PEGDMA) and xanthan gum into the GelMA/alginate system. The inclusion of PEGDMA facilitates tuning of the hydrogel's mechanical property, while xanthan gum improves the viscosity of the hydrogel system and allows easy extrusion at room temperature. To fine-tune the mechanical and degradation properties, methacrylated xanthan gum was synthesized and chemically crosslinked to the system. We systematically characterized this hydrogel with attention to printability, strut size, mechanical property, degradation and cytocompatibility, and achieved a broad range of compression modulus (∼10-100 kPa) and degradation profile (100% degradation by 24 h-40% by 2 weeks). Moreover, xanthan gum demonstrated solubility in ionic solutions such as cell culture medium, which is essential for biocompatibility. Live/dead staining showed that cell viability in the printed hydrogels was over 90% for 7 days. Metabolic activity analysis demonstrated excellent cell proliferation and survival within 4 weeks of incubation. In summary, the newly developed hydrogel system has demonstrated distinct features including extrusion printability, widely tunable mechanical property and degradation, ionic solubility, and cytocompatibility. It offers great flexibility in bioprinting and tissue engineering.

Indexed as

BioprintingTissue ScaffoldsAlginatesGelatinHydrogelsMethacrylatesPolyethylene GlycolsPolysaccharides, BacterialPrinting, Three-DimensionalTissue EngineeringAlginatesGelatingelatin methacryloylHydrogelsMethacrylatespoly(ethylene glycol)-dimethacrylatePolyethylene GlycolsPolysaccharides, Bacterialxanthan gumBioprintingDirect extrusionGelMA/alginate bioinkTissue engineeringXanthan gum

Identifiers

PMID36566553
PMCPMC9868087
OpenAlexW4311764826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.