Evidence map›Paper›PMID 36566464›Full record

ArticleJournal of animal science2023

Genetic and phenotypic associations of mitochondrial DNA copy number, SNP, and haplogroups with growth and carcass traits in beef cattle.

Leticia P Sanglard, Warren M Snelling, Larry A Kuehn, R Mark Thallman, Harvey C Freetly, Tommy L Wheeler, Steven D Shackelford, D Andy King, Matthew L Spangler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Association between mitochondrial DNA copy number and production traits in pigs.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025
    Article
  3. The association ofArchives animal breeding · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Leticia P SanglardDepartment of Animal Science, University of Nebraska, Lincoln, NE 68583, USA.ORCID 0000-0003-4722-8152
Warren M SnellingUSDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.
Larry A KuehnUSDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.ORCID 0000-0002-7573-5365
R Mark ThallmanUSDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.
Harvey C FreetlyUSDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.
Tommy L WheelerUSDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.
Steven D ShackelfordUSDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.
D Andy KingUSDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.
Matthew L SpanglerDepartment of Animal Science, University of Nebraska, Lincoln, NE 68583, USA.
Roman L. Hruska U.S. Meat Animal Research Center · USUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial DNA copy number (mtDNA CN) is heritable and easily obtained from low-pass sequencing (LPS). This study investigated the genetic correlation of mtDNA CN with growth and carcass traits in a multi-breed and crossbred beef cattle population. Blood, leucocyte, and semen samples were obtained from 2,371 animals and subjected to LPS that resulted in nuclear DNA (nuDNA) and mtDNA sequence reads. Mitochondrial DNA CN was estimated as the ratio of mtDNA to nuDNA coverages. Variant calling was performed from mtDNA, and 11 single nucleotide polymorphisms (SNP) were identified in the population. Samples were classified in taurine haplogroups. Haplogroup and mtDNA type were further classified based on the 11 segregating SNP. Growth and carcass traits were available for between 7,249 and 60,989 individuals. Associations of mtDNA CN, mtDNA haplogroups, mtDNA types, and mtDNA SNP with growth and carcass traits were estimated with univariate animal models, and genetic correlations were estimated with a bivariate animal model based on pedigree. Mitochondrial DNA CN tended (P-value ≤0.08) to be associated with birth weight and weaning weight. There was no association (P-value >0.10) between mtDNA SNP, haplogroups, or types with growth and carcass traits. Genetic correlation estimates of mtDNA CN were -0.30 ± 0.16 with birth weight, -0.31 ± 0.16 with weaning weight, -0.15 ± 0.14 with post-weaning gain, -0.11 ± 0.19 with average daily dry-matter intake, -0.04 ± 0.22 with average daily gain, -0.29 ± 0.13 with mature cow weight, -0.11 ± 0.13 with slaughter weight, -0.14 ± 0.13 with carcass weight, -0.07 ± 0.14 with carcass backfat, 0.14 ± 0.14 with carcass marbling, and -0.06 ± 0.14 with ribeye area. In conclusion, mtDNA CN was negatively correlated with most traits investigated, and the genetic correlation was stronger with growth traits than with carcass traits.

Indexed as

DNA, MitochondrialMeatAnimalsBirth WeightCattleDNA Copy Number VariationsFemaleLipopolysaccharidesPhenotypePolymorphism, Single NucleotideDNA, MitochondrialLipopolysaccharidesbeef cattlecarcassgenetic correlationgrowthlow-pass sequencingmtDNA copy numbermtDNA haplogroupsmtDNA SNP

Identifiers

PMID36566464
PMCPMC9841156
OpenAlexW4312140435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.