Evidence map›Paper›PMID 36566338›Full record

ArticleJournal of cancer research and clinical oncology2023

High-dose chemotherapy and autologous stem cell transplantation in primary lymphomatoid granulomatosis of the central nervous system.

Verena Nilius-Eliliwi, Hannes Treiber, Sabine Seidel, Deepak B Vangala, Roland Schroers

Open access · hybridAbstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Verena Nilius-Eliliwi *Department of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, In Der Schornau 23-25, 44892, Bochum, Germany.
Hannes Treiber *Department of Hematology and Oncology, University of Göttingen, Göttingen, Germany.
Sabine SeidelDepartment of Neurology, Knappschaftskrankenhaus, Ruhr-University, Bochum, Germany.
Deepak B VangalaDepartment of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, In Der Schornau 23-25, 44892, Bochum, Germany.
Roland SchroersDepartment of Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, In Der Schornau 23-25, 44892, Bochum, Germany. Roland.Schroers@rub.de.
Ruhr University Bochum · DEUniversitätsklinikum Knappschaftskrankenhaus Bochum · DEUniversity of Göttingen · DE

Funding

Research School, Ruhr University Bochum,Germany 1224444
6 · The paper itself

Abstract

Primary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare lymphoid neoplasia associated Epstein-Barr Virus (EBV) and often accompanied by immunodeficiencies. No treatment standards have been defined yet. However, due to often devastating neurologic sequelae and based on similarities to diffuse large B-cell lymphoma, curative treatment requires intensive therapy protocols resembling protocols applied in CNS lymphoma. Here, the clinical courses and treatments of four primary CNS-LG patients in analogy to aggressive CNS-lymphomas including methotrexate, thiotepa, cytarabine, carmustine, and rituximab are presented. This is the first report on high-dose chemotherapy with CNS-directed drugs and autologous blood stem cell transplantation in primary CNS-LG.

Indexed as

Antineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsCentral Nervous System Viral DiseasesEpstein-Barr Virus InfectionsLymphomatoid GranulomatosisPeripheral Blood Stem Cell TransplantationAdultCarmustineCytarabineFemaleHumansMaleMethotrexateMiddle AgedRituximabThiotepaAntineoplastic AgentsCarmustineCytarabineMethotrexateRituximabThiotepaAutologous stem cell transplantation (ASCT)Central nervous system (CNS)High-dose chemotherapy (HCT)Lymphomatoid granulomatosis (LG)

Identifiers

PMID36566338
PMCPMC10356680
OpenAlexW4312140741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.