Evidence map›Paper›PMID 36566278›Full record

ArticleScientific reports2022

Unravelling the genetics of non-random fertilization associated with gametic incompatibility.

Audrey A A Martin, Samir Id-Lahoucine, Pablo A S Fonseca, Christina M Rochus, Lucas M Alcantara, Dan Tulpan, Stephen J LeBlanc, Filippo Miglior, Joaquim Casellas, Angela Cánovas and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Audrey A A MartinCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Samir Id-LahoucineCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Pablo A S FonsecaCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Christina M RochusCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Lucas M AlcantaraCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Dan TulpanCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Stephen J LeBlancOntario Veterinary College, University of Guelph, Guelph, ON, Canada.
Filippo MigliorCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Joaquim CasellasDepartament de Ciència Animal I Dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Angela CánovasCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Christine F BaesCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
Flavio S SchenkelCentre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada. schenkel@uoguelph.ca.
University of Guelph · CAUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the dairy industry, mate allocation is dependent on the producer's breeding goals and the parents' breeding values. The probability of pregnancy differs among sire-dam combinations, and the compatibility of a pair may vary due to the combination of gametic haplotypes. Under the hypothesis that incomplete incompatibility would reduce the odds of fertilization, and complete incompatibility would lead to a non-fertilizing or lethal combination, deviation from Mendelian inheritance expectations would be observed for incompatible pairs. By adding an interaction to a transmission ratio distortion (TRD) model, which detects departure from the Mendelian expectations, genomic regions linked to gametic incompatibility can be identified. This study aimed to determine the genetic background of gametic incompatibility in Holstein cattle. A total of 283,817 genotyped Holstein trios were used in a TRD analysis, resulting in 422 significant regions, which contained 2075 positional genes further investigated for network, overrepresentation, and guilt-by-association analyses. The identified biological pathways were associated with immunology and cellular communication and a total of 16 functional candidate genes were identified. Further investigation of gametic incompatibility will provide opportunities to improve mate allocation for the dairy cattle industry.

Indexed as

GenomeGerm CellsAnimalsCattleFemaleFertilizationGenotypeHaplotypesPregnancy

Identifiers

PMID36566278
PMCPMC9789956
OpenAlexW4312121565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.