Evidence map›Paper›PMID 36566132›Full record

ArticleTrends in pharmacological sciences2023

Advancing drug discovery for glomerulopathies using stem-cell-derived kidney models.

Amanda D Barreto, Morgan A Burt, Samira Musah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Kidney Disease Modeling with Organoids and Organs-on-Chips.Annual review of biomedical engineering · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amanda D BarretoDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC 27708, USA.
Morgan A BurtDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Samira MusahDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Cell Biology, Duke University, Durham, NC 27710, USA; Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC 27708, USA; Developmental and Stem Cell Biology Program, Duke MEDx Investigator, Duke University, Durham, NC 27710, USA; Duke Regeneration Center, Duke University, Durham, NC 27710, USA. Electronic address: samira.musah@duke.edu.

Funding

University Training Program in Biomolecular and Tissue EngineeringT32GM144291 · NIGMS · DUKE UNIVERSITY · PI Charles A. Gersbach, Tatiana Segura · 2022 to 2026
$2.6M
NIGMS NIH HHS T32 GM144291
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is an epidemic that affects millions worldwide. The glomerulus, a specialized unit of the nephron, is highly susceptible to injury. Human induced pluripotent stem cells (iPSCs) have emerged as an attractive resource for modeling kidney disease and therapeutic discovery.

Indexed as

Induced Pluripotent Stem CellsKidney DiseasesCell DifferentiationDrug DiscoveryHumansKidneydrug discoveryin vitro modelskidney diseasekidney organoidorgan-on-a-chipstem cells

Identifiers

PMID36566132
PMCPMC10885854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.