Evidence map›Paper›PMID 36565971›Full record

ArticleNeuroImage2023

MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe.

Dengrong Jiang, Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat, Emma Lucke, Abhay Moghekar, Jay J Pillai, Hanzhang Lu

Abstract read
In one paragraph

Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dengrong JiangThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: djiang9@jhmi.edu.
Peiying LiuThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Zixuan LinThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Kaisha HazelThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
George PottanatThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Emma LuckeDepartment of Biology, Johns Hopkins University School of Arts & Sciences, Baltimore, MD, United States.
Abhay MoghekarDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Jay J PillaiThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Hanzhang LuThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States.

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Mechanisms of age-related white matter hyperintensities: insights from advanced MRIRF1NS110041 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GE, YULIN, WISNIEWSKI, THOMAS M · 2018 to 2018
$3.6M
An integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7M
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkersUF1NS100588 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., LU, HANZHANG · 2021 to 2021
$2.6M
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseR01AG064792 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2020 to 2023
$2.6M
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal modelsRF1AG071515 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2021 to 2021
$2.4M
MR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2M
MRI assessment of cerebral oxygen extraction fraction (OEF) in the medial temporal lobe as a biomarker in Alzheimer's diseaseR21AG079098 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2022 to 2022
$450k
NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG064792NIA NIH HHS R21 AG079098NIA NIH HHS RF1 AG071515NIBIB NIH HHS P41 EB031771NICHD NIH HHS P50 HD103538NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711NINDS NIH HHS RF1 NS110041NINDS NIH HHS UF1 NS100588
6 · The paper itself

Abstract

The medial temporal lobe (MTL) is a key area implicated in many brain diseases, such as Alzheimer's disease. As a functional biomarker, the oxygen extraction fraction (OEF) of MTL may be more sensitive than structural atrophy of MTL, especially at the early stages of diseases. However, there is a lack of non-invasive techniques to measure MTL-OEF in humans. The goal of this work is to develop an MRI technique to assess MTL-OEF in a clinically practical time without using contrast agents. The proposed method measures venous oxygenation (Y

Indexed as

Cerebral VeinsOxygenAdultAgedBrainCaffeineCerebrovascular CirculationHumansMagnetic Resonance ImagingOxygen ConsumptionCaffeineOxygenAgingAlzheimer's diseaseBasal vein of RosenthalMedial temporal lobeOxygen extraction fractionVenous oxygenation

Identifiers

PMID36565971
PMCPMC9878351

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.