Evidence map›Paper›PMID 36565964›Full record

ArticleJournal of affective disorders2023

Maternal antenatal depression's effects on child developmental delays: Gestational age, postnatal depressive symptoms, and breastfeeding as mediators.

Diane L Putnick, Erin M Bell, Akhgar Ghassabian, Pauline Mendola, Rajeshwari Sundaram, Edwina H Yeung

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Diane L PutnickEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA. Electronic address: putnickd@mail.nih.gov.
Erin M BellDepartment of Environmental Health Sciences, University at Albany School of Public Health, USA.
Akhgar GhassabianDepartments of Pediatrics, Environmental Medicine, and Population Health, New York University Grossman School of Medicine, USA.
Pauline MendolaDepartment of Epidemiology and Environmental Health, University at Buffalo School of Public Health and Health Professions, USA.
Rajeshwari SundaramBiostatistics and Bioinformatics Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA.
Edwina H YeungEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNew York University · USUniversity at Albany, State University of New York · USUniversity at Buffalo, State University of New York · US

Funding

Infertility Treatment, Child Growth and Development Through Age Three YearsZIAHD008826 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2009 to 2025
$9.4M
Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD008826NICHD NIH HHS HHSN267200700019CNICHD NIH HHS HHSN275201200005C
6 · The paper itself

Abstract

backgroundMaternal antenatal depression experienced around conception or during pregnancy may adversely affect child development. This study explores three potential mechanisms of the effects of antenatal depression on children's developmental delays at 2-3 years: gestational age of the child, continued depressive symptoms postnatally, and interrupted breastfeeding practices.

methodsMothers (N = 2888) of 3450 children, including 2303 singletons and 1147 multiples from the Upstate KIDS cohort provided data. Linked hospital discharge data was combined with mothers' reports to identify women with moderate to severe antenatal depression. Gestational age was extracted from birth certificates. Mothers completed a depression screener at 4 months postpartum, reported about their breastfeeding practices from 4 to 12 months postpartum, and completed a developmental delay screener when children were 24, 30, and 36 months.

resultsIn unadjusted path analysis models, mothers with antenatal depression had more postnatal depressive symptoms and breastfed fewer months, which translated into children being more likely to have developmental delays. Gestational age was not a mediator. Effects were similar across girls and boys and singletons and twins, and largely held when adjusting for covariates. LIMITATIONS: Main limitations were the relatively advantaged sample and reliance on maternal report.

conclusionsMaternal antenatal depression may impact child development through continued depressive symptoms in the postpartum period and through reduced breastfeeding duration suggesting additional targets for intervention.

Indexed as

Breast FeedingDepression, PostpartumChildDepressionFemaleHumansMaleMothersPostpartum PeriodPregnancyAntenatal depressionBreastfeedingChild developmentPostnatal depression

Identifiers

PMID36565964
PMCPMC9885303
OpenAlexW4312140852

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.