Evidence map›Paper›PMID 36565939›Full record

ArticleToxicology and applied pharmacology2023

Novel method to assess resident alveolar macrophage efferocytosis of apoptotic neutrophils by flow cytometry.

Jared Radbel, Jaclynn A Meshanni, Carol R Gardner, Oanh Le-Hoang, Jessica Cervelli, Jeffrey D Laskin, Andrew J Gow, Debra L Laskin

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jared RadbelDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, United States of America. Electronic address: Jr1106@rwjms.rutgers.edu.
Jaclynn A MeshanniDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Carol R GardnerDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Oanh Le-HoangDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, United States of America.
Jessica CervelliDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Jeffrey D LaskinDepartment of Environmental and Occupational Health and Justice, School of Public Health, Rutgers University, Piscataway, NJ 08854, United States of America.
Andrew J GowDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Debra L LaskinDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Rutgers, The State University of New Jersey · USJohnson University · US

Funding

UMDNJ/Rutgers University CounterACT Research Center of ExcellenceU54AR055073 · NIAMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI LASKIN, JEFFREY D · 2006 to 2024
$71.4M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
ACTIVATED MACROPHAGES AND OZONE TOXICITYR01ES004738 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Debra L Laskin · 1989 to 2026
$9.0M
Harnessing Inflammatory Macrophages to Thwart Lung Disease Caused by Chronic Ozone ExposureR01ES033698 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI Debra L Laskin · 2022 to 2026
$2.8M
Role of Macrophage Efferocytosis in Ozone-Induced ARDSK08ES031678 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI RADBEL, JARED M. · 2020 to 2024
$1.1M
Mechanisms underlying susceptibility to ozone-induced ARDSR01HL183635 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI JARED M. RADBEL · 2026 to 2026
$555k
Beckman Coulter MoFlo Astrios EQ Cell SorterS10OD026876 · OD · RUTGERS, THE STATE UNIV OF N.J. · PI LASKIN, DEBRA L · 2019 to 2019
$504k
NHLBI NIH HHS R01 HL183635NIAMS NIH HHS U54 AR055073NIEHS NIH HHS K08 ES031678NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R01 ES004738NIEHS NIH HHS R01 ES033698NIEHS NIH HHS T32 ES007148NIH HHS S10 OD026876
6 · The paper itself

Abstract

Macrophage efferocytosis of apoptotic neutrophils (PMNs) plays a key role in the resolution of inflammation. In these studies, we describe a novel flow cytometric method to assess efferocytosis of apoptotic PMNs. Resident alveolar macrophages and PMNs were collected from lungs of mice exposed to inhaled ozone (0.8 ppm, 3 h) followed by lipopolysaccharide (3 mg/kg, i.v.) to induce acute lung injury. PMNs were labeled with PKH26 or DilC

Indexed as

Macrophages, AlveolarNeutrophilsAnimalsApoptosisFlow CytometryInflammationMiceOrganic ChemicalsPhagocytosisOrganic ChemicalsPKH 26Acute lung injuryAlveolar macrophagesEfferocytosisFlow cytometryNeutrophilsOzone

Identifiers

PMID36565939
PMCPMC9870943
OpenAlexW4312140422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.