Evidence map›Paper›PMID 36565799›Full record

ArticleThe American journal of medicine2023

Nontraditional Risk Factors for Progression Through Chronic Kidney Disease Risk Categories: The Coronary Artery Risk Development in Young Adults Study.

Yuni Choi, David R Jacobs, Holly J Kramer, Gautam R Shroff, Alexander R Chang, Daniel A Duprez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Inflammatory and Cardiovascular Events in CKD: The Multi-Ethnic Study of Atherosclerosis (MESA).American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Observational
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yuni ChoiDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis.
Holly J KramerDepartments of Public Health Sciences and Medicine, Loyola University Chicago, Maywood, Ill.
Gautam R ShroffDivision of Cardiology and Department of Medicine, Hennepin Healthcare, University of Minnesota Medical School, Minneapolis.
Alexander R ChangDepartment of Population of Health Sciences, Kidney Health Research Institute, Department of Nephrology, Geisinger Medical Center, Danville, Penn.
Daniel A DuprezCardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis. Electronic address: dupre007@umn.edu.
University of Minnesota · USGeisinger Medical Center · USLoyola University Chicago · US

Funding

VASCULAR CALCIUM--AN EPIDEMIOLOGIC STUDYR01HL048050 · NHLBI · UNIVERSITY OF IOWA · PI MAHONEY, LARRY T · 1992 to 2004
$3.0M
REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSIONR01HL048048 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI BOGGARAM, VIJAYAKUMAR · 1998 to 2006
$1.3M
CORONARY ARTERY DISEASE RISK DEVELOPMENT IN YOUNG ADULTS-N01HC95095-268095095N01HC095095 · HC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAMS, DALE · 1989 to 2006
$376k
STUDY CORONARY HEART DISEASE RISK IN YOUNG ADULTSN01HC048050 · HC · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIDNEY, STEPHEN · 1985 to 2000
$102k
STUDY CORONARY HEART DISEASE RISK IN YOUNG ADULTSN01HC048048 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SCHREINER, PAMELA J · 1985 to 2000
$53k
REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSIONR29HL048048 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI BOGGARAM, VIJAYAKUMAR · 1993 to 1997
–
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01 HC095095
6 · The paper itself

Abstract

backgroundThere may be nontraditional pathways of chronic kidney disease (CKD) progression that are complementary to classical pathways. Therefore, we aimed to examine nontraditional risk factors for incident CKD and its progression.

methodsWe used the generally healthy population (n = 4382) starting at age 27-41 years in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, which is an observational longitudinal study. Nontraditional risk factors included forced vital capacity, inflammation, serum urate, and serum carotenoids. CKD risk category was classified using the estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) measured in 1995-1996 and repeated every 5 years for 20 years: No CKD, low risk, moderate risk, high risk, and very high risk.

resultsAt baseline, 84.8% had no CKD (eGFR ≥60 mL/min/1.73 m

conclusionSeveral nontraditional markers were significantly associated with an increased risk of progression to higher CKD categories in generally healthy young to middle-aged adults.

Indexed as

Coronary VesselsRenal Insufficiency, ChronicAdultAlbuminuriaBiomarkersDisease ProgressionGlomerular Filtration RateHumansLongitudinal StudiesMiddle AgedRisk FactorsUric AcidYoung AdultBiomarkersUric AcidAntioxidant markerChronic kidney disease progressionInflammatory markerLongitudinal studyLung function markerSerum urate

Identifiers

PMID36565799
PMCPMC10038875
OpenAlexW4312141313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.