ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Mayo-PACC: A parsimonious preclinical Alzheimer's disease cognitive composite comprised of public-domain measures to facilitate clinical translation.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Modelling the temporal evolution of plasma p-tau217, amyloid PET, tau PET and cognition.Brain : a journal of neurology · 2026Article
- Development and validation of the lifetime sense of safety scale in Kenyan adults.Communications medicine · 2026Article
- Combining p-tau217 and digital cognitive testing to predict cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of cardiorespiratory fitness with brain white matter microstructural integrity and white matter hyperintensity volume across the adult lifespan.GeroScience · 2026Article
- Telehealth-delivered multimodal mind-body intervention for mild cognitive impairment: a randomized feasibility trial toward scalable dementia prevention.NPJ dementia · 2026Article
- Enhanced sensitivity to plasma p-tau217 with proper names recall in the preclinical Alzheimer's cognitive composite.Brain communications · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Reliability of remote self-administered web-based digital cognitive measures and comparison to in-person neuropsychological tests: Stricker Learning Span, Symbols Test and the Mayo Test Drive Screening Battery Composite.medRxiv : the preprint server for health sciences · 2025Article
- The Parkinson's Disease Cognitive Composite: Lessons Forgotten from Preclinical Alzheimer's Cognitive Composites.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Associations of cardiorespiratory fitness with cerebral cortical thickness and gray matter volume across the adult lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Maximizing utility of neuropsychological measures in sex-specific predictive models of incident Alzheimer's disease in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts.Journal of the American Heart Association · 2024Article
- Examining a Preclinical Alzheimer's Cognitive Composite for Telehealth Administration for Reliability Between In-Person and Remote Cognitive Testing with Neuroimaging Biomarkers.Journal of Alzheimer's disease : JAD · 2024Article
- Continuous Associations between Remote Self-Administered Cognitive Measures and Imaging Biomarkers of Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2024Article
- Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change.Acta neuropathologica · 2023Article
- Usability of the Mayo Test Drive remote self-administered web-based cognitive screening battery in adults aged 35-100 with and without cognitive impairment.Journal of clinical and experimental neuropsychologyArticle
- Remote digital cognitive assessment in a trial-ready Alzheimer's disease cohort: A scalable approach for early intervention studies.Alzheimer's & dementia (New York, N. Y.)Article
- Reliability of remote self-administered Web-based digital cognitive measures and comparison to in-person neuropsychological tests: Stricker Learning Span, Symbols Test, and the Mayo Test Drive Screening Battery Composite.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
11 authors.
Funding
Abstract
introductionWe aimed to define a Mayo Preclinical Alzheimer's disease Cognitive Composite (Mayo-PACC) that prioritizes parsimony and use of public domain measures to facilitate clinical translation.
methodsCognitively unimpaired participants aged 65 to 85 at baseline with amyloid PET imaging were included, yielding 428 amyloid negative (A-) and 186 amyloid positive (A+) individuals with 7 years mean follow-up. Sensitivity to amyloid-related cognitive decline was examined using slope estimates derived from linear mixed models (difference in annualized change across A+ and A- groups). We compared differences in rates of change between Mayo-PACC and other composites (A+ > A- indicating more significant decline in A+).
resultsAll composites showed sensitivity to amyloid-related longitudinal cognitive decline (A+ > A- annualized change p < 0.05). Comparisons revealed that Mayo-PACC (AVLT sum of trials 1-5+6+delay, Trails B, animal fluency) showed comparable longitudinal sensitivity to other composites. DISCUSSION: Mayo-PACC performs similarly to other composites and can be directly translated to the clinic.
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