Evidence map›Paper›PMID 36565421›Full record

ReviewMolecular biology reports2023

Genetic advances in Meniere Disease.

Qingqing Dai, Lili Long, Hui Zhao, Ruikai Wang, Hong Zheng, Maoli Duan

Open access · hybridFull text readReview
In one paragraph

Review in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Genetic contributions to familial Ménière's disease: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  4. The Impact of Genetic Factors in Ménière's Disease.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Qingqing Dai *Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.ORCID http://orcid.org/0000-0003-3064-8310
Lili Long *Department of Otorhinolaryngology, Sichuan University Hospital of Sichuan University, Chengdu, 610065, Sichuan, China.ORCID http://orcid.org/0000-0002-3200-3834
Hui ZhaoDepartment of Otorhinolaryngology, Hospital of Civil Aviation Flight University of China, Guanghan, 618300, Sichuan, China.
Ruikai WangWest China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
Hong ZhengDepartment of Otorhinolaryngology-Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.ORCID http://orcid.org/0000-0002-0199-2940
Maoli DuanDepartment of Otolaryngology-Head and Neck, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institute, 17176, Stockholm, Sweden. maoli.duan@ki.se.ORCID http://orcid.org/0000-0002-8437-1583
Sichuan University · CNKarolinska University Hospital · SECivil Aviation Flight University of China · CN

Funding

Sichuan Health Care Commission project Zh2020-102
6 · The paper itself

Abstract

Meniere Disease (MD) is an idiopathic inner ear disease with complex etiology and pathogenesis, which is still unclear. With the development in gene analysis technology, the genetic research of MD has attracted extensive attention, resulting in a large number of studies on the research of the relationship between human genes and MD. This paper aims to review the studies on this topic in recent years. The studies mainly focused on the genetics of familial MD and the correlation between MD and potentially related functional genes. The results of these studies have demonstrated the complexity and diversity of the pathogenesis of MD with both genetic and epigenetic alterations, suggesting that MD might be related to inflammation, immunity, aqua and ion balance in the lymphatic fluid, virus infection, metabolism, and abnormal function of nerve conduction. The finding of rare mutations in TECTA, MYO7A and OTOG genes and other genes such as CDH23, PCDH15 and ADGRV1 in the same families suggest that the integrity of the stereocilia and their interaction with the tectorial and otolithic membranes could be involved in the pathophysiology of familial MD.

Indexed as

Meniere DiseaseAllelesHumansMutationEtiologyGeneMeniere DiseasePathogenesis

Identifiers

PMID36565421
PMCPMC10011279
OpenAlexW4312129249

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read13
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.