Evidence map›Paper›PMID 36565314›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2023

Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction.

Nadine Spielmann, Christina Schenkl, Tímea Komlódi, Patricia da Silva-Buttkus, Estelle Heyne, Jana Rohde, Oana V Amarie, Birgit Rathkolb, Erich Gnaiger, Torsten Doenst and 4 more

Abstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nadine Spielmann *Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-2699-0068
Christina Schenkl *Department of Cardiothoracic Surgery, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich Schiller University of Jena, Am Klinikum 1, 07747, Jena, Germany.ORCID http://orcid.org/0000-0002-6393-7832
Tímea KomlódiOroboros Instruments, Schöpfstr. 18, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-9876-1411
Patricia da Silva-ButtkusInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-4705-3399
Estelle HeyneDepartment of Cardiothoracic Surgery, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich Schiller University of Jena, Am Klinikum 1, 07747, Jena, Germany.ORCID http://orcid.org/0000-0002-1401-4679
Jana RohdeInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-3213-7920
Oana V AmarieInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-1705-6812
Birgit RathkolbInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-1239-0547
Erich GnaigerOroboros Instruments, Schöpfstr. 18, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-3647-5895
Torsten DoenstDepartment of Cardiothoracic Surgery, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich Schiller University of Jena, Am Klinikum 1, 07747, Jena, Germany.ORCID http://orcid.org/0000-0002-6411-909X
Helmut FuchsInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-5143-2677
Valérie Gailus-DurnerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-6076-0111
Martin Hrabě de Angelis *Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany. hrabe@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-7898-2353
Marten Szibor *Department of Cardiothoracic Surgery, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich Schiller University of Jena, Am Klinikum 1, 07747, Jena, Germany. marten.szibor@med.uni-jena.de.ORCID http://orcid.org/0000-0003-4029-160X

Funding

Deutsche Forschungsgemeinschaft SCHE2126/1-1European Union's Horizon 2020 research and innovation programme 859770German Federal Ministry of Education and Research 01KX1012Hungarian Brain Research Program 2017-1.2.1-NKP-2017-00002Hungarian Scientific Research Fund 143627National Research, Development and Innovation Fund, Hungary TKP2021-EGA-25Semmelweis Egyetem STIA-OTKA-2021
6 · The paper itself

Abstract

Ubiquinol cytochrome c reductase hinge protein (UQCRH) is required for the electron transfer between cytochrome c

Indexed as

Blood GlucoseFailure to ThriveAnimalsElectron Transport Complex IIIEnergy MetabolismHumansMiceMice, KnockoutReactive Oxygen SpeciesTranscription FactorsBlood GlucoseElectron Transport Complex IIIReactive Oxygen SpeciesTranscription Factors

Identifiers

PMID36565314
PMCPMC10290608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.