Evidence map›Paper›PMID 36565279›Full record

ArticleGlia2023

Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury.

Brian T David, Jessica J Curtin, Jennifer L Brown, Kerri Scorpio, Veena Kandaswamy, David J C Coutts, Ana Vivinetto, Paola Bianchimano, Saravanan S Karuppagounder, Mariajose Metcalfe and 2 more

Open access · greenAbstract read
In one paragraph

Article in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Brian T DavidBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0001-8470-802X
Jessica J CurtinBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0002-3529-2168
Jennifer L BrownBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0002-7525-5986
Kerri ScorpioBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0002-1161-2809
Veena KandaswamyBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0001-5517-3599
David J C CouttsBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0003-0527-007X
Ana VivinettoBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0001-5054-6974
Paola BianchimanoBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0003-0550-8682
Saravanan S KaruppagounderBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0002-3440-7170
Mariajose MetcalfeBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0002-5016-8739
John W CaveInVitro Cell Research, LLC, Englewood, New Jersey, USA.ORCID https://orcid.org/0000-0003-1792-7219
Caitlin E HillBurke Neurological Institute, White Plains, New York, USA.ORCID https://orcid.org/0000-0002-7356-2843
Cornell University · USDwight Englewood School · US

Funding

Using transcription factors to enhance transplanted cell survival for SCI repairR01NS075375 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI HILL, CAITLIN ELIZABETH · 2014 to 2017
$2.0M
Burke Foundation, White Plains, NYNIH: NINDS NS075375NINDS NIH HHS R01 NS075375Regenerative Research Foundation, Rensselaer, NYSpinal Cord Injury Trust Fund through the New York State Department of Health C029128Spinal Cord Injury Trust Fund through the New York State Department of Health C030081
6 · The paper itself

Abstract

Hypoxic preconditioning is protective in multiple models of injury and disease, but whether it is beneficial for cells transplanted into sites of spinal cord injury (SCI) is largely unexplored. In this study, we analyzed whether hypoxia-related preconditioning protected Schwann cells (SCs) transplanted into the contused thoracic rat spinal cord. Hypoxic preconditioning was induced in SCs prior to transplantation by exposure to either low oxygen (1% O

Indexed as

Spinal Cord InjuriesAnimalsCell SurvivalCell TransplantationHypoxiaRatsSchwann Cellsadaptaquincell survivaldeferoxaminehypoxia adaptationshypoxia inducible factorpreconditioningprolyl hydroxylase inhibitionspinal cord injurytransplant

Identifiers

PMID36565279
PMCPMC11848738
OpenAlexW4312129472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.