Evidence map›Paper›PMID 36565192›Full record

ArticleJournal of the American Heart Association2023

Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial Integrity.

Tram Anh Vu Nguyen, Caroline Antunes Lino, Huynh Thuy Hang, Juliano Vilela Alves, Bui Quoc Thang, Seung Jae Shin, Kaori Sugiyama, Hiroko Matsunaga, Haruko Takeyama, Yoshito Yamashiro and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. ILK-Dependent Modulation of DPP4 Prevents Progression of Calcific Aortic Valve Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Tram Anh Vu NguyenLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Japan.ORCID 0000-0002-4320-7672
Caroline Antunes LinoDepartment of Anatomy University of Sao Paulo, Institute of Biomedical Sciences Sao Paulo Brazil.
Huynh Thuy HangLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Japan.ORCID 0000-0002-2548-4916
Juliano Vilela AlvesDepartment of Pharmacology University of Sao Paulo, Ribeirao Preto Medical School Ribeirao Preto Brazil.ORCID 0000-0002-6555-5547
Bui Quoc ThangLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Japan.ORCID 0000-0001-8748-4965
Seung Jae ShinLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Japan.
Kaori SugiyamaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Japan.
Hiroko MatsunagaResearch organization for Nano and Life Innovation Waseda University Tokyo Japan.ORCID 0000-0002-1725-3333
Haruko TakeyamaInstitute for Advanced Research of Biosystem Dynamics, Waseda Research Institute for Science and Engineering, Waseda University Tokyo Japan.ORCID 0000-0002-2058-8185
Yoshito YamashiroLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Japan.ORCID 0000-0002-3556-9585
Hiromi YanagisawaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Japan.ORCID 0000-0002-7576-9186
University of Tsukuba · JPUniversidade de São Paulo · BRWaseda University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Homeostasis of the vessel wall is cooperatively maintained by endothelial cells (ECs), smooth muscle cells, and adventitial fibroblasts. The genetic deletion of fibulin-4 (

Indexed as

Aortic Aneurysm, ThoracicEndothelial CellsAnimalsAortaArteriesCalcium-Binding ProteinsHumansMiceMyocytes, Smooth MuscleCalcium-Binding Proteinsfibulinaneurysmaortic valveendothelial cellsfibulin‐4smooth muscle cells

Identifiers

PMID36565192
PMCPMC9973605
OpenAlexW4313524274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.