Observational studyJournal of the American Heart Association2023
Predicting Arterial Thrombotic Events Following Peripheral Revascularization Using Objective Viscoelastic Data.
Observational study in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Thromboelastography With Platelet Mapping to Guide Thromboprophylaxis Following Lower Extremity Revascularization for Peripheral Artery Disease
Personalizing Post Surgical Thromboprophylaxis for Patients With Peripheral Artery Disease
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Thromboelastography and clinical outcomes in peripheral arterial disease: a systematic review and narrative synthesis.Annals of the Royal College of Surgeons of England · 2026Pooled it
- Thromboelastography to Support Clinical Decision Making in Patients with Peripheral Artery Disease.Diagnostics (Basel, Switzerland) · 2025Article
- Association Between Smoking and Thromboelastography With Platelet Mapping Parameters in Peripheral Artery Disease Patients.The Journal of surgical research · 2025Article
- Sex Differences in Platelet Response to Common Antiplatelet Medications.Annals of vascular surgery · 2025Article
- Anti-Inflammatory and Antiplatelet Interactions on PAF and ADP Pathways of NSAIDs, Analgesic and Antihypertensive Drugs for Cardioprotection-In Vitro Assessment in Human Platelets.Medicina (Kaunas, Lithuania) · 2025Article
- Association of age on thromboelastography coagulation profiles among elderly patients with peripheral arterial disease.Journal of vascular surgery · 2025Observational
- Thromboelastography Use: Sex, a Possible Predictor of Thrombosis in Peripheral Artery Disease.The Journal of surgical research · 2025Article
- Association of Chronic Limb Ischemia Rutherford Classification with Clinical Outcomes Following Lower Extremity Revascularization.Annals of vascular surgery · 2025Article
- Racial Variability in Platelet Response Among Patients With Peripheral Artery Disease.The Journal of surgical research · 2025Observational
- Predicting bleeding risk in PAD patients on antiplatelets using TEG coagulation testing.Journal of surgery and research · 2025Article
- Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia.JVS-vascular science · 2025Article
- Using machine learning models to predict post-revascularization thrombosis in PAD.Frontiers in artificial intelligence · 2025Article
- The Use of Clot Strength as a Predictor of Thrombosis in Peripheral Artery Disease.Annals of vascular surgery · 2024Observational
- The impact of sex on platelet responses to aspirin in patients with peripheral artery disease.American journal of hematology · 2024Observational
- Atorvastatin Effect on Clopidogrel Efficacy in Patients with Peripheral Artery Disease.Annals of vascular surgery · 2023Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Background Peripheral artery disease is endemic in our globally aging population, with >200 million affected worldwide. Graft/stent thrombosis after revascularization is common and frequently results in amputation, major adverse cardiovascular events, and cardiovascular mortality. Optimizing medications to decrease thrombosis is of paramount importance; however, limited guidance exists on how to use and monitor antithrombotic therapy in this heterogeneous population. Thromboelastography with platelet mapping (TEG-PM) provides comprehensive coagulation metrics and may be integral to the next stage of patient-centered thrombophrophylaxis. This prospective study aimed to determine if TEG-PM could predict subacute graft/stent thrombosis following lower extremity revascularization, and if objective cut point values could be established to identify those high-risk patients. Methods and Results We conducted a single-center prospective observational study of patients undergoing lower extremity revascularization. Patients were followed up for the composite end point postoperative graft/stent thrombosis at 1 year. TEG-PM analysis of the time point before thrombosis in the event group was compared with the last postoperative visit in the nonevent group. Cox proportional hazards analysis examined the association of TEG-PM metrics to thrombosis. Cut point analysis explored the predictive capacity of TEG-PM metrics for those at high risk. A total of 162 patients were analyzed, of whom 30 (18.5%) experienced graft/stent thrombosis. Patients with thrombosis had significantly greater platelet aggregation (79.7±15.7 versus 58.5±26.4) and lower platelet inhibition (20.7±15.6% versus 41.1±26.6%) (all
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.