Evidence map›Paper›PMID 36565178›Full record

ArticleJournal of the American Heart Association2023

Long-Term Clinical Outcomes in Patients With Severe Tricuspid Regurgitation.

Naoki Nishiura, Takeshi Kitai, Taiji Okada, Madoka Sano, Norihisa Miyawaki, Kitae Kim, Ryosuke Murai, Toshiaki Toyota, Yasuhiro Sasaki, Natsuhiko Ehara and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

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  19. Short-term outcome after isolated tricuspid valve surgery: prognostic role of right ventricular strain.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Naoki NishiuraDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0002-0440-9351
Takeshi KitaiDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0003-2416-5865
Taiji OkadaDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0002-8878-3446
Madoka SanoDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.
Norihisa MiyawakiDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0001-6770-7164
Kitae KimDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0001-5751-5775
Ryosuke MuraiDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0002-7866-0266
Toshiaki ToyotaDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.
Yasuhiro SasakiDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.
Natsuhiko EharaDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0001-9212-3953
Atsushi KoboriDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0002-5360-5009
Makoto KinoshitaDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0002-1325-7177
Tadaaki KoyamaDepartment of Cardiothoracic Surgery Kobe City Medical Center General Hospital Kobe Japan.
Yutaka FurukawaDepartment of Cardiovascular Medicine Kobe City Medical Center General Hospital Kobe Japan.ORCID 0000-0003-4585-2437
Kobe City Medical Center General Hospital · JPNational Cerebral and Cardiovascular Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The natural history and optimal interventional timing in patients with isolated severe tricuspid regurgitation (TR) have not been well studied. This study aimed to investigate long-term clinical outcomes and risk factors associated with poor prognosis in patients with isolated severe TR. Methods and Results Consecutive transthoracic echocardiographic examinations in 2877 patients with isolated severe TR were retrospectively reviewed. Patients with significant left-sided valve disease or repeated examinations were excluded. Primary outcome was defined as a composite of all-cause death and hospitalization for heart failure. Among the 613 enrolled patients (mean age, 74±13 years; men, 38%), 141 died, and 62 were hospitalized for heart failure during the median follow-up period of 26.5 (interquartile range, 6.0-57.9) months. The 5-year event-free rate was 60.1%. TR pressure gradient (adjusted hazard ratio [HR], 1.03 [95% CI, 1.01-1.04]), blood urea nitrogen (adjusted HR, 1.02 [95% CI, 1.01-1.04]), left atrial volume index (adjusted HR, 1.01 [95% CI, 1.002-1.02]), and serum albumin (adjusted HR, 0.56 [95% CI, 0.36-0.95]) were identified as independent predictors of adverse events. A risk model based on the 4 clinical factors that included pulmonary hypertension (TR pressure gradient >40 mm Hg), elevated blood urea nitrogen levels (>25 mg/dL), decreased albumin levels (<3.7 g/dL), and left atrial enlargement (left atrial volume index <34 mL/m

Indexed as

Atrial FibrillationHeart FailureHypertension, PulmonaryTricuspid Valve InsufficiencyAgedAged, 80 and overAlbuminsFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesAlbuminsheart failureprognosissurgerytricuspid regurgitationvalvular heart disease

Identifiers

PMID36565178
PMCPMC9973603
OpenAlexW4313524097

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.