Evidence map›Paper›PMID 36565070›Full record

ArticleJournal of neonatal-perinatal medicine2023

Clinical determinants and impact of hemorrhagic lesions on intestinal pathology in preterm infants with surgical necrotizing enterocolitis.

P M Garg, M X Denton, R Talluri, M M Ostrander, C Middleton, H Sonani, N Varshney, W B Hillegass

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neonatal-perinatal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Clinical utilization of intestinal pathology in the classification of NEC vs SIP cases and prognostication.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

P M GargDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
M X DentonDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
R TalluriDepartment of Data Sciences, University of Mississippi Medical Center, Jackson, Mississippi, USA.
M M OstranderDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
C MiddletonDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
H SonaniDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
N VarshneyDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
W B HillegassDepartment of Data Sciences, University of Mississippi Medical Center, Jackson, Mississippi, USA.
University of Mississippi Medical Center · USJackson Memorial Hospital · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

objectiveWe sought to determine the clinical and histopathological factors associated with intestinal hemorrhage and its correlation with clinical outcomes in neonates with surgical necrotizing enterocolitis (NEC).

methodsA retrospective study compared clinical and histopathology information in neonates following surgical NEC with severe hemorrhage and those with mild/moderate hemorrhagic lesions seen on resected intestine pathology.

resultsThe infants with severe hemorrhage (Grade 3-4, 81/148, 54.7%) had significantly lower exposure to antenatal steroids (52.5 % vs 76.9 %; p = 0.004), had higher gestational age (28.5 weeks [7.14] vs. 26.58 [2.90]; p = 0.034), lost more bowel length (p = 0.045), had higher CRP levels at 2 weeks (p = 0.035), and had less intestinal failure ([30.3 % vs 52.5 %]; p = 0.014) than mild/moderate (Grade 0-2, 67/148, 45.2%) hemorrhage group. Those with severe hemorrhage had significantly higher mean inflammation score (2.67 [0.94] vs. 1.63 [0.92]; p = <0.001), higher necrosis scores (1.95 [1.28] vs. 1.49 [1.35]; p = 0.037), higher neovascularization (p = 0.01), higher fibroblasts (p = 0.023) and higher lymphocyte percentages up to 48 hours (p < 0.05) following NEC than mild/ moderate hemorrhage group.On multivariable regression, less exposure to antenatal steroids (OR 0.18 [95% CI 0.05-0.58]; p = 0.005), higher inflammation (OR 3.7 [95% CI 2.09-7.32]; p = 0.001), and lymphocyte count on the day of onset/24 hours following NEC (OR 1.06 [95% CI 1.02-1.11]; p = 0.005) were independently associated with a higher odd of severe intestinal hemorrhage.

conclusionThe surgical NEC infants with intestinal hemorrhage were less likely to have antenatal steroid exposure but had higher inflammation grade and lymphocyte counts following NEC onset on multivariable regression modeling.

Indexed as

Enterocolitis, NecrotizingFetal DiseasesInfant, Newborn, DiseasesFemaleHemorrhageHumansInfantInfant, NewbornInfant, PrematureInflammationIntestinesPregnancyRetrospective Studiesintestinal hemorrhagenecrotizing enterocolitisoutcomesPreterm infants

Identifiers

PMID36565070
PMCPMC10324376
OpenAlexW4312007605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.