ArticlePlant communications2023
Structural basis of DNA binding by the NAC transcription factor ORE1, a master regulator of plant senescence.
Article in Plant communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Dissecting gene regulatory networks driving grape berry ripening using comparative systems biology across nonclimacteric fleshy fruits: the NAC-centered hierarchy revisited.Horticulture research · 2026Review
- SlSEC1- and SlSPY-mediated O-glycosylation stabilizes the transcription factor SlNOR to promote tomato fruit ripening.The Plant cell · 2026Article
- Cloning and functional analysis of the HaNAC11 transcription factor in Haloxylon ammodendron.BMC plant biology · 2026Article
- The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA.Nature communications · 2026Article
- Regulatory Role of Jasmonate Signaling in Dark-, Drought-, and Salt-Induced Leaf Senescence.International journal of molecular sciences · 2026Review
- DNA binding and dimerization of the SOG1 NAC domain are functionally linked with its ability to undergo liquid-liquid phase separation.Nucleic acids research · 2026Article
- Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A novel-miR-164 from Atractylodes lancea targets AlNAC1 regulating leaf senescence.Plant cell reports · 2025Article
- Analysing protein complexes in plant science: insights and limitation with AlphaFold 3.Botanical studies · 2025Review
- NAC047/052/104 Synergistically Regulate the Dark-Induced Leaf Senescence in Non-Heading Chinese Cabbage.International journal of molecular sciences · 2025Article
- Allovalent scavenging of activation domains in the transcription factor ANAC013 gears transcriptional regulation.Nucleic acids research · 2025Article
- The OsAGO2-OsNAC300-OsNAP module regulates leaf senescence in rice.Journal of integrative plant biology · 2024Article
- Article
- Transcriptional Control of Seed Life: New Insights into the Role of the NAC Family.International journal of molecular sciences · 2024Review
- Genomic and Transcriptomic Insights into the Evolution and Divergence of MIKC-Type MADS-Box Genes inInternational journal of molecular sciences · 2023Article
- CmoNAC1 in pumpkin rootstocks improves salt tolerance of grafted cucumbers by binding to the promoters ofHorticulture research · 2023Article
- Transcription Factors-Regulated Leaf Senescence: Current Knowledge, Challenges and Approaches.International journal of molecular sciences · 2023Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants use sophisticated mechanisms of gene expression to control senescence in response to environmental stress or aging. ORE1 (Arabidopsis thaliana NAC092) is a master regulator of senescence that belongs to the plant-specific NAC transcription factor protein family. ORE1 has been reported to bind to multiple DNA targets to orchestrate leaf senescence, yet the mechanistic basis for recognition of the cognate gene sequence remains unclear. Here, we report the crystal structure of the ORE1-NAC domain alone and its DNA-binding form. The structure of DNA-bound ORE1-NAC revealed the molecular basis for nucleobase recognition and phosphate backbone interactions. We show that local versatility in the DNA-binding site, in combination with domain flexibility of the ORE-NAC homodimer, is crucial for the maintenance of binding to intrinsically flexible DNA. Our results provide a platform for understanding other plant-specific NAC protein-DNA interactions as well as insight into the structural basis of NAC regulators in plants of agronomic and scientific importance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.