ArticleHuman brain mapping2023
Fetal behavior during MRI changes with age and relates to network dynamics.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Roles and applications of artificial intelligence in fetal and placental MRI: a literature review.BMC pregnancy and childbirth · 2026Pooled it
- Human brain R2* transitions across birth from the womb to early infancy.Communications biology · 2025Article
- Comparison of readout-segmented echo-planar imaging and single-shot echo-planar imaging in the fetal brain.Translational pediatrics · 2025Article
- Measuring the effects of motion corruption in fetal fMRI.Human brain mapping · 2025Article
- Whole Brain MRI Assessment of Age and Sex-Related R2* Changes in the Human Fetal Brain.Human brain mapping · 2025Article
- Co-developing sleep-wake and sensory foundations for cognition in the human fetus and newborn.Developmental cognitive neuroscience · 2025Review
- Editorial: Prenatal diagnosis and follow-up of children with CNS abnormalities diagnosed in uterus.Frontiers in neurology · 2025Article
- Revolutionizing Sleep Science: A Narrative Review of the Historical Origins and Current Applications of Sleep Neuroimaging.Nature and science of sleep · 2025Review
- Prenatal Stress and Maternal Role in Neurodevelopment.Annual review of developmental psychology · 2024Article
- Trajectories of human brain functional connectome maturation across the birth transition.PLoS biology · 2024Article
- Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging.Cold Spring Harbor perspectives in biology · 2024Review
- Fetal neuroimaging applications for diagnosis and counseling of brain anomalies: Current practice and future diagnostic strategies.Seminars in fetal & neonatal medicine · 2024Review
- Fetal behavior during MRI changes with age and relates to network dynamics.Human brain mapping · 2023Article
- Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits.Advances in neurobiology · 2023Article
- Systematic review and meta-analysis of MRI-based sex differences in the human fetal brain.Imaging neuroscience (Cambridge, Mass.)Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fetal motor behavior is an important clinical indicator of healthy development. However, our understanding of associations between fetal behavior and fetal brain development is limited. To fill this gap, this study introduced an approach to automatically and objectively classify long durations of fetal movement from a continuous four-dimensional functional magnetic resonance imaging (fMRI) data set, and paired behavior features with brain activity indicated by the fMRI time series. Twelve-minute fMRI scans were conducted in 120 normal fetuses. Postnatal motor function was evaluated at 7 and 36 months age. Fetal motor behavior was quantified by calculating the frame-wise displacement (FD) of fetal brains extracted by a deep-learning model along the whole time series. Analyzing only low motion data, we characterized the recurring coactivation patterns (CAPs) of the supplementary motor area (SMA). Results showed reduced motor activity with advancing gestational age (GA), likely due in part to loss of space (r = -.51, p < .001). Evaluation of individual variation in motor movement revealed a negative association between movement and the occurrence of coactivations within the left parietotemporal network, controlling for age and sex (p = .003). Further, we found that the occurrence of coactivations between the SMA to posterior brain regions, including visual cortex, was prospectively associated with postnatal motor function at 7 months (r = .43, p = .03). This is the first study to pair fetal movement and fMRI, highlighting potential for comparisons of fetal behavior and neural network development to enhance our understanding of fetal brain organization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.