Evidence map›Paper›PMID 36564757›Full record

ArticleBMC cardiovascular disorders2022

Cryptococcus neoformans endocarditis in an immunocompetentpatient a case report.

Colin N McGuire, Dylan J Walter

Erratum issuedOpen access · goldAbstract readCase Reports
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cryptococcal Endocarditis in Humans-A Narrative Review.Pathogens (Basel, Switzerland) · 2025
    Review
  2. Review
  3. Editorial: Emerging fungal pathogens: perspectives.Frontiers in fungal biology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Colin N McGuireDepartment of Internal Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC, 20007, USA.
Dylan J WalterDepartment of Internal Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC, 20007, USA. dylan.j.walter@medstar.net.ORCID http://orcid.org/0000-0003-4337-5307
Georgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCryptococcus neoformans is an invasive fungal infection commonly affecting immunocompromised patients as pneumonia or meningitis. More rarely, case reports describe Cryptococcus neoformans endocarditis, though nearly exclusively among patients with active immunosuppression, implanted cardiac devices or prosthetic valves. CASE PRESENTATION: We report the case of a patient with underlying substance abuse disorder and systolic heart failure presenting with fever, altered mental status, and shower emboli subsequently found to have native tricuspid valve vegetations and blood cultures positive for cryptococcus neoformans in the absence of immunosuppression.

conclusionsHistorically, Cryptococcus neoformans fungemia manifests clinically as pneumonia or meningitis among the immunosuppressed. There have been rare reports of endocarditis in this population and even fewer reports of native valve endocarditis exist. The present case along with mortality reported in prior literature, suggest suspicion must be maintained in the absence of immunosuppression, even in patients with native valves.

Indexed as

CryptococcosisCryptococcus neoformansEndocarditisMeningitisMeningitis, CryptococcalHumansCryptococcal endocarditisCryptococcal fungemia cardiac manifestationsCryptococcal infection in heart failureCryptococcus neoformans valvular disease

Identifiers

PMID36564757
PMCPMC9786419
OpenAlexW4312178186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.