Evidence map›Paper›PMID 36564578›Full record

ArticleJournal of gastroenterology2023

Nationwide cohort study identifies clinical outcomes of angioectasia in patients with acute hematochezia.

Mariko Kobayashi, Shintaro Akiyama, Toshiaki Narasaka, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Jun Omori, Takashi Ikeya, Taiki Aoyama, Naoyuki Tominaga and 38 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 1 country.

Mariko Kobayashi *Division of Endoscopic Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
Shintaro Akiyama *Department of Gastroenterology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Toshiaki NarasakaDivision of Endoscopic Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan. tnarasaka@md.tsukuba.ac.jp.ORCID 0000-0001-8510-333X
Katsumasa KobayashiDepartment of Gastroenterology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Atsushi YamauchiDepartment of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.
Atsuo YamadaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Jun OmoriDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Takashi IkeyaDepartment of Gastroenterology, St. Luke's International University, Tokyo, Japan.
Taiki AoyamaDepartment of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Naoyuki TominagaDepartment of Gastroenterology, Saga-Ken Medical Centre Koseikan, Saga, Japan.
Yoshinori SatoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Takaaki KishinoDepartment of Gastroenterology and Hepatology, Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan.
Naoki IshiiDepartment of Gastroenterology, Tokyo Shinagawa Hospital, Tokyo, Japan.
Tsunaki SawadaDepartment of Endoscopy, Nagoya University Hospital, Nagoya, Aichi, Japan.
Masaki MurataDepartment of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Akinari TakaoDepartment of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Kazuhiro MizukamiDepartment of Gastroenterology, Oita University, Oita, Japan.
Ken KinjoDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Shunji FujimoriDepartment of Gastroenterology, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.
Takahiro UotaniDepartment of Gastroenterology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan.
Minoru FujitaDivision of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School General Medical Center, Okayama, Japan.
Hiroki SatoDivision of Gastroenterology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Sho SuzukiDepartment of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital, Miyazaki, Japan.
Junnosuke HayasakaDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
Tomohiro FunabikiDepartment of Emergency Medicine, Fujita Health University Hospital, Aichi, Japan.
Yuzuru KinjoDepartment of Gastroenterology, Naha City Hospital, Naha, Okinawa, Japan.
Akira MizukiDepartment of Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Shu KiyotokiDepartment of Gastroenterology, Shuto General Hospital, Yanai, Yamaguchi, Japan.
Tatsuya MikamiDivision of Endoscopy, Hirosaki University Hospital, Aomori, Japan.
Ryosuke GushimaDepartment of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Hiroyuki FujiiDepartment of Gastroenterology and Hepatology, National Hospital Organization Fukuokahigashi Medical Center, Fukuoka, Japan.
Yuta FuyunoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Naohiko GunjiDepartment of Gastroenterology, Fukushima Medical University, Fukushima, Japan.
Yosuke ToyaDivision of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka, Iwate, Japan.
Kazuyuki NarimatsuDepartment of Internal Medicine, National Defense Medical College, Saitama, Japan.
Noriaki ManabeDivision of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Okayama, Japan.
Koji NagaikeDepartment of Gastroenterology and Hepatology, Suita Municipal Hospital, Osaka, Japan.
Tetsu KinjoDepartment of Endoscopy, University of the Ryukyus Hospital, Okinawa, Japan.
Yorinobu SumidaDepartment of Gastroenterology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Sadahiro FunakoshiDepartment of Gastroenterological Endoscopy, Fukuoka University Hospital, Fukuoka, Japan.
Kiyonori KobayashiDepartment of Gastroenterology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
Tamotsu MatsuhashiDepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Yuga KomakiDigestive and Lifestyle Diseases, and Hygiene and Health Promotion Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Kuniko MikiDepartment of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan.
Kazuhiro WatanabeDepartment of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan.
Kiichiro TsuchiyaDepartment of Gastroenterology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Mitsuru KaiseDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Naoyoshi NagataDepartment of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan.
University of Tsukuba · JPKawasaki Medical School · JPNippon Medical School · JPTokyo Medical University · JPTokyo Metropolitan Bokutoh Hospital · JPAkita University · JPChiba Hokusou Hospital · JPFukuoka Higashi Medical Center · JPFukuoka University · JPFukuoka University Hospital · JPFukushima Medical University · JPHirosaki University Hospital · JPHiroshima City Asa Citizens Hospital · JPIwate Medical University · JPKagoshima University · JPKitano Hospital · JPKumamoto University · JPKyoto Medical Center · JPKyushu University · JPNagoya University Hospital · JP

Funding

Grants-in-Aid for Research from the National Center for Global Health and Medicine 19A1011Grants-in-Aid for Research from the National Center for Global Health and Medicine 19A1022Grants-in-Aid for Research from the National Center for Global Health and Medicine 19A-2015Grants-in-Aid for Research from the National Center for Global Health and Medicine 29-1025Grants-in-Aid for Research from the National Center for Global Health and Medicine 29-2001Grants-in-Aid for Research from the National Center for Global Health and Medicine 29-2004Grants-in-Aid for Research from the National Center for Global Health and Medicine 30-1020JSPS KAKENHI 20K08366JSPS KAKENHI JP17K09365Ministry of Health, Labour and Welfare 19HB1003
6 · The paper itself

Abstract

backgroundWhile angioectasia is an important cause of acute hematochezia, relevant clinical features remain unclear. This study aims to reveal risk factors, clinical outcomes, and the effectiveness of therapeutic endoscopy for patients with acute hematochezia due to angioectasia.

methodsThis retrospective cohort study was conducted at 49 Japanese hospitals between January 2010 and December 2019, enrolling patients hospitalized for acute hematochezia (CODE BLUE-J study). Baseline factors and clinical outcomes for angioectasia were analyzed.

resultsAmong 10,342 patients with acute hematochezia, 129 patients (1.2%) were diagnosed with angioectasia by colonoscopy. The following factors were significantly associated with angioectasia: chronic kidney disease, liver disease, female, body mass index < 25, and anticoagulant use. Patients with angioectasia were at a significant increased risk of blood transfusions compared to those without angioectasia (odds ratio [OR] 2.61; 95% confidence interval [CI] 1.69-4.02). Among patients with angioectasia, 36 patients (28%) experienced rebleeding during 1-year follow-up. The 1-year cumulative rebleeding rates were 37.0% in the endoscopic clipping group, 14.3% in the coagulation group, and 32.8% in the conservative management group. Compared to conservative management, coagulation therapy significantly reduced rebleeding risk (P = 0.038), while clipping did not (P = 0.81). Multivariate analysis showed coagulation therapy was an independent factor for reducing rebleeding risk (hazard ratio [HR] 0.40; 95% CI 0.16-0.96).

conclusionsOur data showed patients with angioectasia had a greater comorbidity burden and needed more blood transfusions in comparison with those without angioectasia. To reduce rebleeding risk, coagulation therapy can be superior for controlling hematochezia secondary to angioectasia.

Indexed as

Gastrointestinal HemorrhageNeoplasm Recurrence, LocalCohort StudiesDilatation, PathologicFemaleHumansRecurrenceRetrospective StudiesRisk FactorsAcute hematocheziaClipping therapyCoagulation therapyColonic angioectasiaRebleeding

Identifiers

PMID36564578
OpenAlexW4312110052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.