Evidence map›Paper›PMID 36564563›Full record

ArticleBritish journal of cancer2023

The future burden of oesophageal and stomach cancers attributable to modifiable behaviours in Australia: a pooled cohort study.

Maarit A Laaksonen, Siqi Li, Karen Canfell, Robert J MacInnis, Graham G Giles, Emily Banks, Julie E Byles, Dianna J Magliano, Jonathan E Shaw, Tiffany K Gill and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Dose-response association between cigarette smoking and gastric cancer risk: a systematic review and meta-analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maarit A LaaksonenSchool of Mathematics and Statistics, University of New South Wales, Sydney, NSW, Australia. m.laaksonen@unsw.edu.au.ORCID http://orcid.org/0000-0002-3676-0787
Siqi LiSchool of Mathematics and Statistics, University of New South Wales, Sydney, NSW, Australia.
Karen CanfellDaffodil Centre, The University of Sydney, a joint venture with Cancer Council New South Wales, Sydney, NSW, Australia.
Robert J MacInnisCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-1627-5047
Graham G GilesCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Emily BanksNational Centre for Epidemiology and Population Health, Research School of Population Health, Australian National University, Canberra, ACT, Australia.
Julie E BylesResearch Centre for Generational Health and Ageing, University of Newcastle, Newcastle, NSW, Australia.
Dianna J MaglianoDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Jonathan E ShawClinical Diabetes and Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Tiffany K GillAdelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Vasant HiraniSchool of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Robert G CummingSchool of Public Health, The University of Sydney, Sydney, NSW, Australia.
Paul MitchellCentre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
Michelle BonelloCancer Voices NSW, Sydney, NSW, Australia.
Australian cancer-PAF cohort consortium
Claire M VajdicKirby Institute, University of New South Wales, Sydney, NSW, Australia.

Funding

NCI CLINICAL INVESTIGATOR AWARD PROGRAMK08CA001022 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BUBLEY, GLENN J · 1987 to 1989
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Cancer Institute NSW (Cancer Institute New South Wales) 2019/CDF1022Cancer Institute NSW (Cancer Institute New South Wales) ID13/ECF/1-07Department of Health | National Health and Medical Research Council (NHMRC) 1053642Department of Health | National Health and Medical Research Council (NHMRC) 1060991Department of Health | National Health and Medical Research Council (NHMRC) 1079438Department of Health | National Health and Medical Research Council (NHMRC) 1082989Department of Health | National Health and Medical Research Council (NHMRC) 1118161Department of Health | National Health and Medical Research Council (NHMRC) 1136128
6 · The paper itself

Abstract

backgroundWe quantified the individual and joint contribution of contemporaneous causal behavioural exposures on the future burden of oesophageal and stomach cancers and their subtypes and assessed whether these burdens differ between population groups in Australia, as such estimates are currently lacking.

methodsWe combined hazard ratios from seven pooled Australian cohorts (N = 367,058) linked to national cancer and death registries with exposure prevalence from the 2017-2018 National Health Survey to estimate Population Attributable Fractions (PAFs) with 95% confidence intervals (CIs), accounting for competing risk of death.

resultsCurrent and past smoking explain 35.2% (95% CI = 11.7-52.4%), current alcohol consumption exceeding three drinks/day 15.7% (95% CI = 0.9-28.4%), and these exposures jointly 41.4% (95% CI = 19.8-57.3%) of oesophageal squamous cell carcinomas in Australia. Current and past smoking contribute 38.2% (95% CI = 9.4-57.9%), obesity 27.0% (95% CI = 0.6-46.4%), and these exposures jointly 54.4% (95% CI = 25.3-72.1%) of oesophageal adenocarcinomas. Overweight and obesity explain 36.1% (95% CI = 9.1-55.1%), current and past smoking 24.2% (95% CI = 4.2-40.0%), and these exposures jointly 51.2% (95% CI = 26.3-67.8%) of stomach cardia cancers. Several population groups had a significantly higher smoking-attributable oesophageal cancer burden, including men and those consuming excessive alcohol.

conclusionsSmoking is the leading preventable behavioural cause of oesophageal cancers and overweight/obesity of stomach cancers.

Indexed as

Stomach NeoplasmsAustraliaCohort StudiesHumansIncidenceMaleObesityOverweightRisk Factors

Identifiers

PMID36564563
PMCPMC10006078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.