Evidence map›Paper›PMID 36564457›Full record

ArticleScientific reports2022

Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA).

Othman Benchama, Michael S Malamas, Kulkarni Praveen, Elizabeth C Ethier, Mark K Williams, Alexandros Makriyannis, Hava Karsenty Avraham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Othman BenchamaCenter of Drug Discovery, Northeastern University, Boston, MA, 02115, USA.
Michael S MalamasCenter of Drug Discovery, Northeastern University, Boston, MA, 02115, USA.
Kulkarni PraveenCenter for Translational Neuroimaging, Northeastern University, Boston, MA, 02115, USA.
Elizabeth C EthierCenter of Drug Discovery, Northeastern University, Boston, MA, 02115, USA.
Mark K WilliamsMineral Logic LLC, Kalamazoo, MI, 49048, USA.
Alexandros MakriyannisCenter of Drug Discovery, Northeastern University, Boston, MA, 02115, USA.
Hava Karsenty AvrahamCenter of Drug Discovery, Northeastern University, Boston, MA, 02115, USA. h.avraham@northeastern.edu.
Northeastern University · US

Funding

Project 3 - In vivo pharmacology of cannabinoid receptor probesP01DA009158 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Alexandros Makriyannis · 1994 to 2026
$26.0M
New Modalities for the Treatment of Pain and Drug Abuse-Biochemical CoreP01DA041307 · NIDA · UNIVERSITY OF ARIZONA · PI PORRECA, FRANK · 2017 to 2021
$3.0M
Targeting Inflammasome with stable endocannabinoid ligand AMG315. CRISPR/Cas9 and nanotechnology study in the context of HIV and cannabinoidR01DA052271 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI LAKSHMANA, MADEPALLI KRISHNAPPA, MAKRIYANNIS, ALEXANDROS · 2020 to 2024
$2.2M
NIDA NIH HHS P01 DA009158NIDA NIH HHS P01 DA041307NIDA NIH HHS R01 DA052271
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is associated with high mortality due to the high expression of pro-inflammatory cytokines and lack of targeted therapies. N-acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that promotes inflammatory responses through the deactivation of Palmitoylethanolamide (PEA), an endogenous bioactive lipid mediator. Here, we examined NAAA expression in TNBC cells (MDA-MB-231 and MDA-MB-BrM2 cells) and the effects of NAAA inhibition on TNBC tumor growth, using a selective NAAA inhibitor AM11095 (IC

Indexed as

Triple Negative Breast NeoplasmsAmidesAmidohydrolasesAnimalsEthanolaminesFemaleHumansInflammationMicePlacenta Growth FactorAmidesAmidohydrolasesEthanolaminesNAAA protein, humanN-acylethanolaminesPlacenta Growth Factor

Identifiers

PMID36564457
PMCPMC9789040
OpenAlexW4312155045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.