Evidence map›Paper›PMID 36564414›Full record

ArticleScientific reports2022

Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics.

Vina R Aldilla, Renxun Chen, Rajesh Kuppusamy, Sudip Chakraborty, Mark D P Willcox, David StC Black, Pall Thordarson, Adam D Martin, Naresh Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Plasma-Activated Hydrogels for Microbial Disinfection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  11. Article
  12. Rational Design of Bioactive Materials for Bone Hemostasis and Defect Repair.Cyborg and bionic systems (Washington, D.C.) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vina R AldillaSchool of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.
Renxun ChenSchool of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia. r.chen@unsw.edu.au.
Rajesh KuppusamySchool of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.
Sudip ChakrabortySchool of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.
Mark D P WillcoxSchool of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, 2052, Australia.
David StC BlackSchool of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.
Pall ThordarsonSchool of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.
Adam D MartinFaculty of Medicine and Health Sciences, Dementia Research Centre, Macquarie University, Sydney, NSW, 2109, Australia.
Naresh KumarSchool of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia. n.kumar@unsw.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, L-phenylalanine, a short aliphatic linker, and a cationic group. The synthesized peptide mimics efficiently formed hydrogels with minimum gel concentrations between 0.1 and 0.3%w/v. The resulting hydrogels exhibited desirable viscoelastic properties which can be tuned by varying the cationic group, electronegative substituent, or counter anion. Importantly, nanofibers from the NaA-capped cationic hydrogels were found to be the source of hydrogels' potent bacteriacidal actvity against both Gram-positive and Gram-negative bacteria while remaining non-cytotoxic. These intrinsically antibacterial hydrogels are ideal candidates for further development in applications where bacterial contamination is problematic.

Indexed as

Anti-Bacterial AgentsHydrogelsCationsGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity Testsortho-AminobenzoatesPeptidesanthranilamideAnti-Bacterial AgentsCationsHydrogelsortho-AminobenzoatesPeptides

Identifiers

PMID36564414
PMCPMC9789043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.