ReviewTranslational psychiatry2022
Placebo and nocebo effects: from observation to harnessing and clinical application.
Review in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cardiac rehabilitation and health-related quality of life in preserved ejection fraction heart failure: A meta-analysis.ESC heart failure · 2025Pooled it
- Applications of machine learning in deep brain stimulation for major depressive disorder: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Individual differences in dopamine-related traits influence mood effects of dopamine D2-antagonist and antidepressant treatment expectations.The international journal of neuropsychopharmacology · 2025Trial
- Nocebo expectations rather than placebo expectations affect topical pain relief: A randomized clinical trial.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Trial
- Cancer pain.Nature reviews. Disease primers · 2026Review
- Review
- The "Are You OK?" Paradox: A Scoping Review of Nocebo and Negative Suggestion in Healthcare Communication.Dentistry journal · 2026Review
- Measuring and appraising placebo effects in clinical trials: contemporary challenges and approaches in psychiatry.The lancet. Psychiatry · 2026Review
- Healing vs. hurting words: the power of language in pain perception-a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Auricular acupuncture as stress-relieving intervention for parents of infants in the neonatal intensive care unit: insights gained from a pilot study.Frontiers in global women's health · 2025Article
- Exploring "Service" versus "Education" in Anesthesiology Postgraduate Medical Training: Getting Answers but Not Always Asking the Right Questions.Advances in medical education and practice · 2025Article
- Article
- Differential neural activity predicts the long-term stability of the effects of positive and negative expectations on pain.Scientific reports · 2024Article
- GutWomen's health reports (New Rochelle, N.Y.) · 2024Article
- Negative expectations (nocebo phenomenon) in clinical interventions: A scoping review.Journal of education and health promotion · 2024Article
- Words hurt: common and distinct neural substrates underlying nociceptive and semantic pain.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placebo and nocebo effects are salubrious benefits and negative outcomes attributable to non-specific symbolic components. Leveraging advanced experimental and analytical approaches, recent studies have elucidated complicated neural mechanisms that may serve as a solid basis for harnessing the powerful self-healing and self-harming capacities and applying these findings to improve medical practice and minimize the unintended exacerbation of symptoms in medical practice. We review advances in employing psychosocial, pharmacological, and neuromodulation approaches to modulate/harness placebo and nocebo effects. While these approaches show promising potential, translating these research findings into clinical settings still requires careful methodological, technical, and ethical considerations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.