Evidence map›Paper›PMID 36564206›Full record

ArticleNeurology2023

Pearls & Oy-sters: Salt and Pepper Sign, PLNTY for Drug-Resistant Epilepsy.

Elma M Paredes-Aragón, Norah A AlKhaldi, Jorge G Burneo, Donald Lee, Lee C Ang, David Steven, Maria MacDonald, Manuel Herrera-Aramburú, Seyed M Mirsattari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic review and cumulative analysis of clinical properties of BRAF V600E mutations in PLNTY histological samples.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Pooled it
  2. Article
  3. Article
  4. Polymorphous low-grade neuroepithelial tumor of the young: case report and literature review.International journal of clinical and experimental pathology · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elma M Paredes-AragónFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru. elma.paredesaragon@lhsc.on.ca.ORCID 0000-0002-2505-8052
Norah A AlKhaldiFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Jorge G BurneoFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.ORCID 0000-0002-3644-2826
Donald LeeFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Lee C AngFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
David StevenFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.ORCID 0000-0002-0392-8950
Maria MacDonaldFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Manuel Herrera-AramburúFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.ORCID 0000-0003-1270-4091
Seyed M MirsattariFrom the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-resistant epilepsy, defined as the failure of 2 or more antiseizure medications to achieve seizure freedom, is responsible for 2/3 of epilepsy cases. Tumors are responsible for up to 15% of all adult onset and up to 6% of childhood onset epilepsies. Among these tumors, commonly known subtypes DNET, ganglioglioma, and low-grade astrocytoma are often suspected. New advances in tumor classification have been made, with genetics playing a key role in tumor classification. Polymorphic low-grade neuroepithelial tumor of the young (PLNTY) is a highly epileptogenic subtype of tumors that may mimic low-grade gliomas but offer pathologic and genetic clues: oligodendroglioma-like cellular components and infiltration patterns and strong CD34-immunopositive stain. In addition, a key finding is radiologic: a unifocal abnormality best seen on MRI brain in FLAIR sequence as the "salt and pepper sign" and calcifications appreciated on CT head.

Indexed as

Brain NeoplasmsDrug Resistant EpilepsyEpilepsyGliomaNeoplasms, NeuroepithelialOligodendrogliomaHumans

Identifiers

PMID36564206
PMCPMC10115500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.