Evidence map›Paper›PMID 36564184›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Prolactin-Releasing Peptide Contributes to Stress-Related Mood Disorders and Inhibits Sleep/Mood Regulatory Melanin-Concentrating Hormone Neurons in Rats.

Szilvia Vas, Rege S Papp, Katalin Könczöl, Emese Bogáthy, Noémi Papp, Csaba Ádori, Máté Durst, Klaudia Sípos, Klementina Ocskay, Imre Farkas and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 3 countries.

Szilvia VasDepartment of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.
Rege S PappHuman Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, 1094, Hungary.
Katalin KönczölLaboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.
Emese BogáthyDepartment of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.
Noémi PappDepartment of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.
Csaba ÁdoriDepartment of Neuroscience, Karolinska Institutet, Stockholm, 17177, Sweden.
Máté DurstLaboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.
Klaudia SíposLaboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.
Klementina OcskayLaboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.
Imre FarkasLaboratory of Reproductive Neurobiology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.ORCID 0000-0002-0159-4408
Flóra BálintLaboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
Szilamér FerenciLaboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
Bibiána TörökLaboratory of Behavioral and Stress Studies, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
Anita KovácsInstitute of Physiology, Medical School, University of Pécs, Centre for Neuroscience, Szentágothai Research Center, Pécs, 7624, Hungary.
Evelin SzabóInstitute of Physiology, Medical School, University of Pécs, Centre for Neuroscience, Szentágothai Research Center, Pécs, 7624, Hungary.
Dóra ZelenaLaboratory of Behavioral and Stress Studies, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.ORCID 0000-0001-5616-1100
Krisztina J KovácsLaboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
Anna FöldesDepartment of Oral Biology, Semmelweis University, Budapest, 1089, Hungary.
Erzsébet KatóDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1089, Hungary.
László KölesDepartment of Oral Biology, Semmelweis University, Budapest, 1089, Hungary.
György BagdyDepartment of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.
Miklós PalkovitsHuman Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, 1094, Hungary.
Zsuzsanna E TóthLaboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary toth.zsuzsanna.emese@med.semmelweis-univ.hu.
Semmelweis University · HUHUN-REN Institute of Experimental Medicine · HUEötvös Loránd University · HUUniversity of Pecs · HUKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress disorders impair sleep and quality of life; however, their pathomechanisms are unknown. Prolactin-releasing peptide (PrRP) is a stress mediator; we therefore hypothesized that PrRP may be involved in the development of stress disorders. PrRP is produced by the medullary A1/A2 noradrenaline (NA) cells, which transmit stress signals to forebrain centers, and by non-NA cells in the hypothalamic dorsomedial nucleus. We found in male rats that both PrRP and PrRP-NA cells innervate melanin-concentrating hormone (MCH) producing neurons in the dorsolateral hypothalamus (DLH). These cells serve as a key hub for regulating sleep and affective states.

Indexed as

Hypothalamic HormonesSleep DeprivationAnimalsHumansMaleMelaninsMood DisordersNeuronsNorepinephrinePituitary HormonesProlactin-Releasing HormoneQuality of LifeRatsRats, WistarSleepHypothalamic Hormonesmelanin-concentrating hormoneMelaninsNorepinephrinePituitary HormonesProlactin-Releasing HormoneGABA(A) receptorMCHmental disorderssleepstresssuicide

Identifiers

PMID36564184
PMCPMC9899089
OpenAlexW4312129777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.