ArticleJournal of the American Academy of Child and Adolescent Psychiatry2023
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06484088 (Characterizing the Brain Circuitry and Neural Activity Mediating Frustration), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing the Brain Circuitry and Neural Activity Mediating Frustration
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability.Translational psychiatry · 2026Review
- SHAP-based explainable machine learning analysis of reward-related neural connectivity to predict preadolescent irritability.Neuroimage. Reports · 2026Article
- Associations Between Neighborhood Resources and Youths' Response to Reward Omission in a Task Modeling Negatively Biased Environments.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Frustrative Nonreward: Behavior, Circuits, Neurochemistry, and Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Multivariate Assessment of Inhibitory Control in Youth: Links With Psychopathology and Brain Function.Psychological science · 2024Article
- Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024Review
- A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice.Biological psychiatry global open science · 2024Article
- Concurrent and prospective associations between infant frontoparietal and default mode network connectivity and negative affectivity.Biological psychology · 2023Article
- Robust caregiver-youth discrepancies in irritability ratings on the affective reactivity index: An investigation of its origins.Journal of affective disorders · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveAberrant responses to frustration are central mechanisms of pediatric irritability, which is a common reason for psychiatric consultation and a risk factor for affective disorders and suicidality. This pilot study aimed to characterize brain network configuration during and after frustration and test whether characteristics of networks formed during or after frustration relate to irritability.
methodDuring functional magnetic resonance imaging, a transdiagnostic sample enriched for irritability (N = 66, mean age = 14.0 years, 50% female participants) completed a frustration-induction task flanked by pretask and posttask resting-state scans. We first tested whether and how the organization of brain regions (ie, nodes) into networks (ie, modules) changes during and after frustration. Then, using a train/test/held-out procedure, we aimed to predict past-week irritability from global efficiency (E
resultsTwo modules present in the baseline pretask resting-state scan (one encompassing anterior default mode and temporolimbic regions and one consisting of frontoparietal regions) contributed most to brain circuit reorganization during and after frustration. Only E
conclusionThese pilot results suggest the importance of the postfrustration recovery period in the pathophysiology of irritability. E
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.