Evidence map›Paper›PMID 36563734›Full record

ArticlePhysiology & behavior2023

Enhancement of allyl isothiocyanate-evoked responses of mouse trigeminal ganglion cells by the kokumi substance γ-glutamyl-valyl-glycine (γ-EVG) through activation of the calcium-sensing receptor (CaSR).

Tasuku Akiyama, Eric Curtis, M Iodi Carstens, E Carstens

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Tasuku AkiyamaDept. of Dermatology & Cutaneous Surgery, Univ. of Miami Miller School of Medicine, Miami FL United States of America.
Eric CurtisDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, California, United States of America.
M Iodi CarstensDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, California, United States of America.
E CarstensDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, California, United States of America. Electronic address: eecarstens@ucdavis.edu.
University of California, Davis · USUniversity of California System · USUniversity of Miami · US

Funding

Spinal mechanisms of itchR01AR057194 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARSTENS, EARL E · 2009 to 2019
$3.4M
Trigeminal Mechanisms of Oral IrritationR01DE013685 · NIDCR · UNIVERSITY OF CALIFORNIA DAVIS · PI CARSTENS, EARL E · 2001 to 2009
$2.1M
Role of NK-1 receptors in descending modulation and ascending transmission of itchR01AR076434 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARSTENS, EARL E · 2020 to 2024
$1.7M
NIAMS NIH HHS R01 AR057194NIAMS NIH HHS R01 AR076434NIDCR NIH HHS R01 DE013685
6 · The paper itself

Abstract

Some γ-glutamyl peptides including glutathione (γ-Glu-Cys-Gly) and γ-glutamyl-valyl-glycine (γ-Glu-Val-Gly= γ-EVG) are reported to increase the intensity of basic tastes, such as salty, sweet, and umami, although they have no taste themselves at tested concentrations. The mechanism of action of γ-glutamyl peptides is not clearly understood, but the calcium sensing receptor (CaSR) may be involved. Glutathione and γ-EVG enhance the pungency of some spices, and the present study investigated the effects of γ-EVG on the responses of trigeminal ganglion (TG) cells to thermosensitiveTRP channel agonists. Single-cell RT-PCR revealed that most CaSR-expressing cells co-expressed TRPV1 (sensitive to capsaicin) and TRPA1 (sensitive to allyl isothiocyanate= AITC). Intracellular Ca

Indexed as

CapsaicinReceptors, Calcium-SensingAnimalsGlutathioneIsothiocyanatesMiceOligopeptidesTrigeminal GanglionTRPA1 Cation Channel2,3,4-tri-O-acetylarabinopyranosyl isothiocyanateallyl isothiocyanateCapsaicinglutamyl-valyl-glycineGlutathioneIsothiocyanatesOligopeptidesReceptors, Calcium-SensingTRPA1 Cation ChannelCalcium-sensing receptor (CasR), Calcium imaging, Immunohistochemistry, TRPA1, TRPV1, Kokumi substanceTrigeminal ganglion cell

Identifiers

PMID36563734
PMCPMC10239685
OpenAlexW4312083276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.