ArticleScience advances2022
Extremophile-based biohybrid micromotors for biomedical operations in harsh acidic environments.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Micro/Nanorobots (MNRs) at the Intersection of Mechanobiology and Artificial Intelligence: An Emerging Frontier for Precision Nanomedicine.ACS nano medicine · 2026Review
- Oral colon targeted curcumin-based nanocomposite inulin hydrogel for alleviating intestinal inflammation and dysbiosis.Journal of nanobiotechnology · 2026Article
- Photocatalytic Micro/Nanomotors Functioning in the Near-Infrared Window for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Living photosynthetic micro/nano-platforms: Engineering unicellular algae for biomedical applications.Bioactive materials · 2025Review
- Unlocking the potential of microalgae-derived therapeutic carriers: Characteristics, types, and nanomedical applications.Materials today. Bio · 2025Review
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Picoeukaryote-based biohybrid microrobots for active delivery in the kidney.Science advances · 2025Article
- Microalgae-driven microrobots: revolutionizing drug delivery and targeted therapy in biopharmaceuticals.Advanced biotechnology · 2025Review
- Inhalable biohybrid microrobots: a non-invasive approach for lung treatment.Nature communications · 2025Article
- Oral administration microrobots for drug delivery.Bioactive materials · 2024Review
- Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis.Science advances · 2024Article
- Light-controlled soft bio-microrobot.Light, science & applications · 2024Article
- Biohybrid Microalgae Robots: Design, Fabrication, Materials, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Micro/nanorobots for gastrointestinal tract.Frontiers in chemistry · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of robots in extreme environments is regarded as one of the major challenges facing robotics. Here, we demonstrate that acidophilic microalgae biomotors can maintain their swimming behavior over long periods of time in the harsh acidic environment of the stomach, thus enabling them to be applied for gastrointestinal (GI) delivery applications. The biomotors can also be functionalized with a wide range of cargos, ranging from small molecules to nanoparticles, without compromising their ability to self-propel under extreme conditions. Successful GI delivery of model payloads after oral administration of the acidophilic algae motors is confirmed using a murine model. By tuning the surface properties of cargos, it is possible to modulate their precise GI localization. Overall, our findings indicate that multifunctional acidophilic algae-based biomotors offer distinct advantages compared to traditional biohybrid platforms and hold great potential for GI-related biomedical applications.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.