Evidence map›Paper›PMID 36563142›Full record

ArticleScience advances2022

Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling.

Yoshiko Nakamura, Takaki Yahiro, Akihiro Fukushima, Naoya Kataoka, Hiroyuki Hioki, Kazuhiro Nakamura

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 44 citations in OpenAlex.

  1. The Japanese Society of Hypertension Practical Consensus Guidelines for Seasonal Blood Pressure Management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026
    Review
  6. Article
  7. Review
  8. The pyrogenic mediator prostaglandin EThe Journal of physiology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Body Temperature Regulation in the Rat by Muscle Tone.Acta physiologica (Oxford, England) · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yoshiko NakamuraDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0002-3491-0825
Takaki YahiroDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0001-7396-5442
Akihiro FukushimaDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0003-4465-7445
Naoya KataokaDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0002-2339-5522
Hiroyuki HiokiDepartment of Neuroanatomy, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-0152-7854
Kazuhiro NakamuraDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0002-6095-8996
Nagoya University · JPJuntendo University · JPNagoya University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bidirectional controller of the thermoregulatory center in the preoptic area (POA) is unknown. Using rats, here, we identify prostaglandin EP3 receptor-expressing POA neurons (POA

Indexed as

Body TemperatureReceptors, ProstaglandinAnimalsBody Temperature RegulationFeverNeuronsProstaglandinsRatsReceptors, Prostaglandin E, EP3 SubtypeProstaglandinsReceptors, ProstaglandinReceptors, Prostaglandin E, EP3 Subtype

Identifiers

PMID36563142
PMCPMC9788766
OpenAlexW4312179351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.