Evidence map›Paper›PMID 36563047›Full record

ArticleJournal of neurochemistry2023

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance.

João Victor Cabral-Costa, Carlos Vicente-Gutiérrez, Jesús Agulla, Rebeca Lapresa, John W Elrod, Ángeles Almeida, Juan P Bolaños, Alicia J Kowaltowski

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. The role of mitochondrial Na⁺/Ca²⁺ exchanger in brain cell aging.Journal of bioenergetics and biomembranes · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Role of mitochondrial CaMolecular medicine reports · 2025
    Review
  8. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Differential CaFrontiers in synaptic neuroscience · 2025
    Article
  13. Calcium Ions in the Physiology and Pathology of the Central Nervous System.International journal of molecular sciences · 2024
    Review
  14. MCU genetically altered mice suggest how mitochondrial CaTrends in endocrinology and metabolism: TEM · 2024
    Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

João Victor Cabral-CostaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-5441-1807
Carlos Vicente-GutiérrezInstitute of Functional Biology and Genomics, University of Salamanca-CSIC, Salamanca, Spain.ORCID 0000-0002-6481-595X
Jesús AgullaInstitute of Functional Biology and Genomics, University of Salamanca-CSIC, Salamanca, Spain.ORCID 0000-0001-9574-2549
Rebeca LapresaInstitute of Functional Biology and Genomics, University of Salamanca-CSIC, Salamanca, Spain.ORCID 0000-0001-8901-3972
John W ElrodCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3925-2224
Ángeles AlmeidaInstitute of Functional Biology and Genomics, University of Salamanca-CSIC, Salamanca, Spain.ORCID 0000-0003-0485-8904
Juan P BolañosInstitute of Functional Biology and Genomics, University of Salamanca-CSIC, Salamanca, Spain.ORCID 0000-0002-3949-6862
Alicia J KowaltowskiDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-3807-2419
Universidad de Salamanca · ESUniversidade de São Paulo · BRTemple University · US

Funding

Mitochondria and metabolism in neurodegenerationRF1NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2021 to 2021
$2.3M
Mitochondria and metabolism in neurodegenerationR01NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2024 to 2025
$1.5M
NINDS NIH HHS R01 NS121379NINDS NIH HHS RF1 NS121379
6 · The paper itself

Abstract

Intracellular Ca

Indexed as

AstrocytesCalciumAnimalsCalcium SignalingCognitionGlycolysisMiceMitochondriaSodiumSodium-Calcium ExchangerCalciumSodiumSodium-Calcium Exchangerastrocytebrain metabolismcalcium transportenergy metabolismglycolysislactatemetabolic regulationmitochondrial metabolismNCLXsodium-calcium exchangesodium transport

Identifiers

PMID36563047
PMCPMC10478152
OpenAlexW4312114720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.