ArticleCerebral cortex (New York, N.Y. : 1991)2023
Sex differences in default mode network connectivity in healthy aging adults.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Sleep quality is associated with default mode and salience network connectivity differently across age and sex.Neurobiology of aging · 2026Article
- Article
- Let's talk about sex: Male and female mice show similar fear memory retention despite hippocampal activity differences during encoding and consolidation.bioRxiv : the preprint server for biology · 2026Article
- Conditioned Graph Reconstruction of Brain Functional Network Connectivity Reveals Interpretable Latent Axes of Sex and Fluid Intelligence.bioRxiv : the preprint server for biology · 2026Article
- The progression of sex differences in brain networks across the lifespan.bioRxiv : the preprint server for biology · 2026Article
- A Fragmented Mind: Altered States of Consciousness and Spirit Possession Between Rituals and Therapy.Integrative psychological & behavioral science · 2025Article
- Age and Sex Moderate the Effects of Sleep Quality on Resting-State Functional Connectivity in the Salience and Default Mode Network.Research square · 2025Article
- Sex differences in the executive and behavioral reserve of autosomal dominant frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex difference in language cognition in the elderly group: a near-infrared spectroscopy study.Neurophotonics · 2025Article
- The neurobiology of plant-based therapeutics in women's reproductive health: mechanisms, efficacy, and clinical translation.Frontiers in nutrition · 2025Review
- Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer's disease.Brain communications · 2025Article
- Possible influence of sex on the relationship between dual-task gait costs and cognitive decline in older adults.PloS one · 2025Article
- Sex-specific topological structure associated with dementia via latent space estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Sex differences of signal complexity at resting-state functional magnetic resonance imaging and their associations with the estrogen-signaling pathway in the brain.Cognitive neurodynamics · 2024Article
- A Demographic-Conditioned Variational Autoencoder for fMRI Distribution Sampling and Removal of Confounds.ArXiv · 2024Article
- Somatomotor-visual resting state functional connectivity increases after 2 years in the UK Biobank longitudinal cohort.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Impact of sex and reproductive status on the default mode network in early midlife: implications for aging of memory circuitry and function.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Longitudinal monitoring of the mouse brain reveals heterogenous network trajectories during aging.Communications biology · 2024Article
- Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology.Frontiers in neuroscience · 2024Review
- Identifiability in Functional Connectivity May Unintentionally Inflate Prediction Results.ArXiv · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Women show an increased lifetime risk of Alzheimer's disease (AD) compared with men. Characteristic brain connectivity changes, particularly within the default mode network (DMN), have been associated with both symptomatic and preclinical AD, but the impact of sex on DMN function throughout aging is poorly understood. We investigated sex differences in DMN connectivity over the lifespan in 595 cognitively healthy participants from the Human Connectome Project-Aging cohort. We used the intrinsic connectivity distribution (a robust voxel-based metric of functional connectivity) and a seed connectivity approach to determine sex differences within the DMN and between the DMN and whole brain. Compared with men, women demonstrated higher connectivity with age in posterior DMN nodes and lower connectivity in the medial prefrontal cortex. Differences were most prominent in the decades surrounding menopause. Seed-based analysis revealed higher connectivity in women from the posterior cingulate to angular gyrus, which correlated with neuropsychological measures of declarative memory, and hippocampus. Taken together, we show significant sex differences in DMN subnetworks over the lifespan, including patterns in aging women that resemble changes previously seen in preclinical AD. These findings highlight the importance of considering sex in neuroimaging studies of aging and neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.