ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025
Permanent pacing versus cardioneuroablation for cardioinhibitory vasovagal syncope.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Cardioneuroablation for Reflex Syncope and Functional Bradyarrhythmias: A State-of-the-Art Review.Journal of clinical medicine · 2026Review
- Cardioneuroablation versus cardiac pacemaker in the management of dominant cardioinhibitory vasovagal syncope: a retrospective cohort study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Convolutional neural network for real‑time localization of ganglionated plexi from bipolar intracardiac electrograms.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Efficacy and safety of cardioneuroablation as a treatment for patients with functional bradyarrhythmia: a systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2026Review
- Older age is not an independent predictor of syncope recurrence following cardioneuroablation for reflex syncope.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Observational
- Cardioneuroablation for Refractory Vasovagal Storm Secondary to a Right Hilar Tumor.JACC. Case reports · 2025Article
- Time for a paradigm shift: from pacing to ablation in reflex syncope.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Different time course effect of autonomic nervous modulation after cryoballoon and hotballoon catheter ablations for paroxysmal atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Intracardiac echocardiography and electroanatomical mapping: do we still need fluoroscopy for cardioneuroablation procedures?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Cardioneuroablation for the management of patients with recurrent vasovagal syncope and symptomatic bradyarrhythmias: the CNA-FWRD Registry.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Observational
- Quality of life improvement following cardioneuroablation for vasovagal syncope: expected or too early to say?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Endocardial gaglionated plexi ablation in different vagally-mediated clinical settings: From cardioneuroablation to cardio-neuromodulation.European heart journal supplements : journal of the European Society of Cardiology · 2025Article
- Cardioneuroablation for Asystolic Reflex Syncope: How to Identify the Best Candidate and How to Predict Success.Arrhythmia & electrophysiology review · 2025Review
- Inappropriate Sinus Tachycardia Following Cardioneuroablation for Reflex Syncope: A Case Report and Review of the Literature Illustrating this Underappreciated Adverse Effect.Arrhythmia & electrophysiology review · 2025Article
- Cardioneuroablation can be an effective strategy to treat glossopharyngeal neuralgia-related sinus bradycardia and pauses.Journal of cardiovascular electrophysiology · 2024Article
- Cardioneuroablation for the treatment of ictal-associated cardiac asystole: case report and literature review.European heart journal. Case reports · 2023Article
- Autonomic modulation: Getting it "just right".Heart rhythm O2 · 2023Article
- Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation.Journal of cardiovascular development and disease · 2023Review
- Rate-Responsive Cardiac Pacing: Technological Solutions and Their Applications.Sensors (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
13 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe compared the efficacy and safety of cardioneuroablation (CNA) vs. permanent pacing (PM) for recurrent cardioinhibitory vasovagal syncope (CI-VVS).
methodsOne hundred sixty-two patients (CNA = 61, PM = 101), age 36 + 11 years) with syncope frequency of 6.7 ± 3.9/year were included in this multicenter study. All patients with CNA were provided by a single center, while patients with PM were provided by 4 other centers. In the CNA arm, an electroanatomic mapping guided approach was used to detect and ablate ganglionated plexus sites. Dual chamber rate drop response (RDR) or close loop stimulation (CLS) transvenous and leadless pacemakers were implanted using standard technique. The primary endpoint was freedom from syncope.
resultsOf 101 patients in the PM group, 39 received dual-chamber pacemaker implants with the CLS algorithm, 38 received dual-chamber pacemakers with the RDR algorithm, and 24 received a leadless pacemaker. At 1-year follow-up, 97% and 89% in the CNA and PM group met the primary endpoint (adjusted HR = 0.27, 95% CI 0.06-1.24, p = 0.09). No significant differences in adverse events were noted between groups. There was no significant association between age (HR:1.01, 95% CI 0.96-1.06, p = 0.655), sex (HR:1.15, 95% CI 0.38-3.51, p = 0.809), and syncope frequency in the past year (HR:1.10, 95% CI 0.97-1.25, p = 0.122) and the primary outcome in univariable analyses.
conclusionsAfter adjustment for patient characteristics, the medium-term syncope recurrence risk of CI-VVS patients who underwent CNA was similar to that of a population of patients undergoing pacemaker implantation with a similar safety profile.
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