ReviewCancer causes & control : CCC2023
The impact of social and environmental factors on cancer biology in Black Americans.
Review in Cancer causes & control : CCC, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Hazardous Environmental Pollutants and Cancer Disparities: A Systematic Review on the Consideration of Race and Ethnicity in Environmental Epidemiology Research.Current environmental health reports · 2025Pooled it
- Article
- Assessment of Differences in Colorectal Cancer Outcomes by Geographic Region for Black Patients in the United States.Journal of racial and ethnic health disparities · 2026Article
- Participant Heterogeneity in the Prostate Cancer Biobank of the NRG: An Obstacle to Broadening the Reach of Precision Oncology.JCO precision oncology · 2026Article
- L-SOLCO Pilot Study: Examining Allostatic Load and Cancer Treatment Disparities.Journal of racial and ethnic health disparities · 2026Article
- Historical redlining, breast cancer survival, and the mediating and modifying role of contemporary neighborhood socioeconomic conditions.American journal of epidemiology · 2026Article
- Clinicopathological Characteristics and Survival Outcomes of Gastrointestinal Neuroendocrine Tumors in a Large Safety Net Hospital.Journal of clinical medicine · 2026Article
- Geographical accessibility of cancer hospital using geospatial technology in Bagmati province, Nepal.Frontiers in public health · 2026Article
- Differences in breast cancer outcomes amongst Caribbean born women in Florida, USA-a population-based analysis.Lancet regional health. Americas · 2025Article
- Does inclusion of neighborhood variables improve clinical risk prediction for advanced prostate cancer in Black and White men?Urologic oncology · 2025Article
- Geospatial Genomics: Operationalizing Multilevel Conceptual Frameworks of Cancer Health Outcomes to Account for Gene-Person-Place Relationships.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Multilevel Stressors and Systemic and Tumor Immunity in Black and White Women With Breast Cancer.JAMA network open · 2025Article
- Spatial Clustering for Carolina Breast Cancer Study.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Longitudinal trajectories of a claims-based frailty measure during adjuvant chemotherapy in women with stage I-III breast cancer.The oncologist · 2024Article
- Neighborhood Disadvantage and Prostate Tumor Aggressiveness among African American and European American Men.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- West African Genetic Ancestry, Neighborhood Deprivation, and Prostate Cancer.JAMA network open · 2024Article
- Does structural racism impact receipt of NCCN guideline-concordant breast cancer treatment?Breast cancer research and treatment · 2024Article
- Neighborhood Disadvantage and Prostate Tumor RNA Expression of Stress-Related Genes.JAMA network open · 2024Article
- Prevalence and influencing factors of social alienation among elderly patients undergoing radical prostatectomy for prostate cancer.Current urology · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Low socioeconomic status (SES) is associated with early onset of chronic diseases and reduced life expectancy. The involvement of neighborhood-level factors in defining cancer risk and outcomes for marginalized communities has been an active area of research for decades. Yet, the biological processes that underlie the impact of SES on chronic health conditions, such as cancer, remain poorly understood. To date, limited studies have shown that chronic life stress is more prevalent in low SES communities and can affect important molecular processes implicated in tumor biology such as DNA methylation, inflammation, and immune response. Further efforts to elucidate how neighborhood-level factors function physiologically to worsen cancer outcomes for disadvantaged communities are underway. This review provides an overview of the current literature on how socioenvironmental factors within neighborhoods contribute to more aggressive tumor biology, specifically in Black U.S. women and men, including the impact of environmental pollutants, neighborhood deprivation, social isolation, structural racism, and discrimination. We also summarize commonly used methods to measure deprivation, discrimination, and structural racism at the neighborhood-level in cancer health disparities research. Finally, we offer recommendations to adopt a multi-faceted intersectional approach to reduce cancer health disparities and develop effective interventions to promote health equity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.