Evidence map›Paper›PMID 36562850›Full record

SynthesisJournal of neurology2023

Salivary Aβ

Ziqi Fan, Zheyu Li, Shuai Zhao, Yanxing Chen, Yujie Su, Guoping Peng, Benyan Luo

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Diagnostic performance of salivary markers of Alzheimer's disease: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ziqi Fan *Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Zheyu Li *Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
Shuai ZhaoDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
Yanxing ChenDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
Yujie SuDepartment of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Guoping PengDepartment of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Benyan LuoDepartment of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China. luobenyan@zju.edu.cn.ORCID http://orcid.org/0000-0002-9892-5778
Second Affiliated Hospital of Zhejiang University · CNZhejiang University · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

Key R&D Program of Zhejiang 2022C03064National Natural Science Foundation of China 81870826National Natural Science Foundation of China 82071182
6 · The paper itself

Abstract

objectiveAlzheimer's disease (AD) is the most prevalent form of dementia among the aging population. Cumulative studies aim to find non-invasive biomarkers in the early stages of AD. Saliva can be obtained easily, and salivary biomarkers have been proven effective in detecting neurodegenerative diseases. To find effective biomarkers in saliva and to help the diagnosis of AD, we performed a meta-analysis focusing on the salivary biomarkers (β-amyloid 1-42 (Aβ

methodsWe conducted a systematic online search for eligible studies reporting data on salivary biomarkers reflecting Aβ

resultsA total of thirteen studies were included in the meta-analysis, of them seven involved salivary Aβ

conclusionThe pooled results provide evidence that salivary Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAcetylcholinesteraseBiomarkersHumansPeptide FragmentsSalivatau ProteinsAcetylcholinesteraseAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAcetylcholinesteraseAlzheimer’s diseasePhosphorylated tauSalivary biomarkersTotal tauβ-amyloid 1–42

Identifiers

PMID36562850
OpenAlexW4312114612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.