ArticleSocial psychiatry and psychiatric epidemiology2023
Sedative drug-use in Denmark, 2000 to 2019: a nationwide drug utilization study.
Article in Social psychiatry and psychiatric epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Psychotropic medication use among community dwellers with and without Parkinson's disease - A nationwide cohort study.British journal of clinical pharmacology · 2026Article
- Prescription patterns of anxiolytics in remote consultation versus in-person consultation: a cross-sectional study in French general practice.BJGP open · 2025Article
- Patterns and indications for quetiapine prescribing in Dutch primary care: a retrospective database study.BJGP open · 2025Article
- Exploring nationwide patterns of sleep problems from late adolescence to adulthood using machine learning.Science advances · 2025Article
- A decade of Benzodiazepine and Z-drug use in Hong Kong: a longitudinal study.The Lancet regional health. Western Pacific · 2025Article
- Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation-Structured Literature Review and Analysis.Journal of xenobiotics · 2024Review
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Abstract
aimTo describe trends in and characteristics of sedative drug use from 2000 through 2019 in relation to the introduction of central regulations and new drugs.
methodsIn this descriptive study, we used individual prescription data on the entire Danish population from the Danish National Prescription Registry to calculate yearly incidence and prevalence of use of benzodiazepines, benzodiazepine-related drugs (Z-drugs), melatonin, olanzapine, low-dose quetiapine, mianserin/mirtazapine, pregabalin, and promethazine from 2000 through 2019. From the Danish National Patient Registry, we obtained data on drug users' psychiatric and somatic comorbidity.
resultsThe use of benzodiazepines and Z-drugs declined gradually from 2000 through 2019, whereas the newer alternatives, melatonin, low-dose quetiapine, pregabalin and promethazine, increased in use, while the use of olanzapine and mianserin/mirtazapine was relatively stable. This development was seen in both men and women and across all age groups except for hypnotic benzodiazepines which showed a steep increase in the oldest age group from 2010. For all sedative drugs depression, anxiety, alcohol and misuse disorder, pain and cancer were the most prevalent comorbidities. During our study period, the number of individuals without any of the selected diagnoses increased.
conclusionIn Denmark different central regulations have influenced prescription practice toward more restrictive use of Z-drugs and benzodiazepines, except for hypnotic benzodiazepine prescriptions increased after the introduction of special palliative care. An increase in use of newer sedative drugs, however, indicates that the regulations do not remove the need for sedative drugs in the population.
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