Evidence map›Paper›PMID 36562795›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2023

Periostin regulation and cartilage degradation early after anterior cruciate ligament reconstruction.

Cale A Jacobs, Laura E Keller, Sheng Zhang, Qin Fu, Emily R Hunt, Austin V Stone, Caitlin E W Conley, Christian Lattermann, Lisa A Fortier

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cale A JacobsUniversity of Kentucky, 740 S. Limestone, Suite K401, Lexington, KY, 40536-0284, USA. cjacobs@bwh.harvard.edu.
Laura E KellerCornell University, Ithaca, NY, USA.
Sheng ZhangCornell University, Ithaca, NY, USA.
Qin FuCornell University, Ithaca, NY, USA.
Emily R HuntBrigham and Women's Hospital, MA, Boston, USA.
Austin V StoneUniversity of Kentucky, 740 S. Limestone, Suite K401, Lexington, KY, 40536-0284, USA.
Caitlin E W ConleyUniversity of Kentucky, 740 S. Limestone, Suite K401, Lexington, KY, 40536-0284, USA.
Christian LattermannBrigham and Women's Hospital, MA, Boston, USA.
Lisa A FortierCornell University, Ithaca, NY, USA.
Cornell University · USUniversity of Kentucky · USBrigham and Women's Hospital · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Acquisition of a Hybrid Quadrupole Time of Flight LC-MS/MS System for the CornellS10OD017992 · OD · CORNELL UNIVERSITY · PI ZHANG, SHENG · 2014 to 2014
$600k
NCATS NIH HHS UL1TR001998NIH SIG 1S10 OD017992-01University of Kentucky Multidisciplinary Value Program Initiative
6 · The paper itself

Abstract

OBJECTIVE AND

designThe purpose of this study was to explore pathological processes during the first 4 weeks after anterior cruciate ligament reconstruction (ACLR). SUBJECTS: Sixteen ACL-injured patients (8 females/8 males, mean age = 19.1, mean BMI = 28.6).

methodsArthrocentesis was performed 1 and 4 weeks after ACLR. Proteins in the synovial fluid were identified using nanoLC-ESI-MS/MS. Differentially up- or down-regulated proteins were identified and quantified, and a pathway analysis was performed. All identified proteins were mapped into a protein-protein interaction (PPI) network, and networks of PPIs with a combined score > 0.9 were then visualized.

resultsSeven pathways were upregulated after ACLR: PI3K-AKT signaling pathway, extracellular matrix (ECM)-receptor interaction, focal adhesion, protein digestion and absorption, ameobiasis, and platelet activation. Network analyses identified 8 proteins that were differentially upregulated with strong PPI interactions (periostin and 7 collagen-related proteins). Increases in periostin moderately correlated with increases in a synovial fluid biomarker of type II cartilage degradation (ρ = 0.51, p = 0.06).

conclusionPro-inflammatory pathways and periostin were upregulated after ACLR. Periostin demonstrated strong network connections with markers of collagen breakdown, and future work is needed to determine whether periostin may offer a biomarker of early cartilage degradation after ACLR and/or play an active role in early post-traumatic osteoarthritis (PTOA) progression.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionCartilage, ArticularAdultBiomarkersCell Adhesion MoleculesCollagenFemaleHumansKnee JointMalePhosphatidylinositol 3-KinasesTandem Mass SpectrometryYoung AdultBiomarkersCell Adhesion MoleculesCollagenPhosphatidylinositol 3-KinasesPOSTN protein, humanBiomarkerCartilageKneeNetwork analysisPathway analysisSynovial fluid

Identifiers

PMID36562795
OpenAlexW4312100268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.