Evidence map›Paper›PMID 36562498›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2023

Disentangling global and domain-level adaptive behavior trajectories among children with autism spectrum disorder.

Cristan Farmer, Audrey Thurm, Emma Condy, Eric Duku, Peter Szatmari, Teresa Bennett, Mayada Elsabbagh, Connor M Kerns, Isabel M Smith, Tracy Vaillancourt and 3 more

Abstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cristan FarmerNeurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6878-5199
Audrey ThurmNeurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0489-9485
Emma CondyNeurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Eric DukuMcMaster University, Hamilton, ON, Canada.
Peter SzatmariCentre for Addiction and Mental Health, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Teresa BennettMcMaster University, Hamilton, ON, Canada.
Mayada ElsabbaghMcGill University, Montreal, QC, Canada.
Connor M KernsUniversity of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-0832-8329
Isabel M SmithDalhousie University, Halifax, NS, Canada.
Tracy VaillancourtUniversity of Ottawa, Ottawa, ON, Canada.
Anat Zaidman-ZaitTel Aviv University, Tel Aviv, Israel.
Lonnie ZwaigenbaumUniversity of Alberta, Edmonton, AB, Canada.
Stelios GeorgiadesMcMaster University, Hamilton, ON, Canada.

Funding

Clinical and Behavioral Phenotyping of Autism and Related DisordersZIAMH002868 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SWEDO, SUSAN · 2009 to 2017
$17.8M
Neurodevelopmental and Behavioral Phenotyping ZICMH002961 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI THURM, AUDREY · 2017 to 2025
$12.6M
Intramural NIH HHS ZIA MH002868Intramural NIH HHS ZIC MH002961NIMH NIH HHS ZIAMH002868
6 · The paper itself

Abstract

backgroundHeterogeneity in adaptive behavior abilities among people with autism spectrum disorder (ASD) is expressed not only as uneven levels of impairment across domains, but also in the developmental trajectories of adaptive skills. We studied the question of whether, after accounting for global adaptive behavior development, we find evidence of heterogeneity in the trajectories of specific domains of adaptive behavior.

methodsA sample of 504 children with ASD was obtained by combining data from two independent natural history studies conducted in North America. We used a factor of curves model to explain growth between 36 and 138 months in Vineland Adaptive Behavior Scales, Second Edition (VABS) age equivalents as a function of domain-specific and global growth processes.

resultsThe domain-specific trajectories in all three domains (Communication, Daily Living Skills, and Socialization) reflected impairment relative to age expectations as well as slower-than-expected growth with age, and the parameters of these trajectories were moderately-to-strongly correlated across domains. The global adaptive behavior trajectory had an initial (36-41 months of age) developmental level of about 22 age-equivalent months, and eventually slowed after initially increasing by about 6 months each year. The global trajectory accounted for the majority of variance in the domain-level processes; however, additional variance remained (14%-38%) in the domain-level intercepts, slopes, and quadratic processes.

conclusionsThese results extend existing theoretical and empirical support for the hierarchical structure of adaptive behavior to include its development over time in clinical samples of children with ASD. A latent global trajectory may be sufficient to describe the growth of adaptive behavior in children with ASD; however, the remaining domain-specific variability after accounting for global adaptive behavior development allows for the possibility that differential effects of intervention on specific domains may be possible and detectable.

Indexed as

Autism Spectrum DisorderAdaptation, PsychologicalChildCommunicationHumansInfantadaptive behaviorautism spectrum disorderdevelopmentstructural equation modeling

Identifiers

PMID36562498
PMCPMC10369325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.