ArticleJournal of veterinary internal medicine2023
Sepsis and survival in critically ill calves: Risk factors and antimicrobial use.
Article in Journal of veterinary internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Effects on health and antioxidant status of oral supplementation of hazelnut skin extract in dairy calves with neonatal diarrhea: a randomized clinical trial in hospitalized patients.The veterinary quarterly · 2026Article
- Evaluation of Intestinal Barrier Biomarkers and Glucagon-like Peptide-2 in SIRS-Positive and SIRS-Negative Diarrheic Calves.Animals : an open access journal from MDPI · 2026Article
- Characterizing bacteremia in neonatal calves with diarrhea: a case-control study.Journal of veterinary internal medicine · 2026Article
- Immunomodulatory activities of bovine host defense peptides (HDPs): context-dependent roles in inflammation and immune priming.BMC veterinary research · 2026Article
- Accuracy of two Sepsityper MALDI-TOF MS methods for bacterial identification in bloodstream infections in dogs, foals, and calves using Bayesian latent class model.The veterinary quarterly · 2025Article
- Anion Gap and Ionised Calcium as Diagnostic Indicators in Calves with Atresia Coli from Twenty-Two Cases.Veterinary sciences · 2025Article
- Exploring the therapeutic potential of recombinant bovine β-defensins for antimicrobial and anti-inflammatory functions in sepsis management.Veterinary research · 2025Article
- An on-farm observational study on the prevalence and associated factors of bacteremia in preweaned dairy calves diagnosed with bronchopneumonia by thoracic ultrasonography.BMC veterinary research · 2025Article
- Optimization of Antimicrobial Use for Sepsis in Calves: Bayesian Evaluation of Existing and Novel Sepsis Scores.Animals : an open access journal from MDPI · 2025Article
- Characterization of blood microbial population in beef calves with clinical signs of sepsis using 16S rRNA gene sequencing.PloS one · 2025Article
- TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis.Frontiers in immunology · 2025Article
- Comparative Analysis of Hepatic Gene Expression Profiles in Murine and Porcine Sepsis Models.International journal of molecular sciences · 2024Article
- Long-Term Survival in 241 Cases of Intussusception in Cattle and Factors Associated with Mortality.Animals : an open access journal from MDPI · 2024Article
- Sepsis and survival in critically ill calves: Risk factors and antimicrobial use.Journal of veterinary internal medicine · 2023Article
- Retrospective cohort study on diseases and risk factors associated with death in hospitalized neonatal foals.Journal of veterinary internal medicineArticle
- Thoracic Ultrasonography in Calves: A Narrative Review of Techniques and Reporting Practices.Journal of veterinary internal medicineReview
- Evaluation of the Glutaraldehyde Test as a Prognostic Indicator for Short- and Long-Term Mortality in Hospitalized Adult Cattle With and Without Sepsis.Journal of veterinary internal medicineArticle
- Bayesian evaluation of sensitivity and specificity of blood culture media and hypoglycemia in sepsis-suspected calves.Journal of veterinary internal medicineArticle
- Clinical and laboratory predictors for bacteremia in critically ill calves.Journal of veterinary internal medicineArticle
- Effect of time of sample collection after onset of diarrhea on fecal microbiota composition of calves.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSepsis is a life-threatening disease for which critically important antimicrobials (CIA) frequently are used. Diagnostic and therapeutic guidelines for sepsis and critically ill calves are largely lacking.
objectivesIdentify factors associated with mortality in critically ill calves and describe bacteria obtained from blood cultures of critically ill calves with sepsis and their antimicrobial resistance. ANIMALS: Two-hundred thirty critically ill calves, mainly Belgian Blue beef cattle.
methodsRetrospective cohort study. Logistic regression, survival analysis, and decision tree analysis were used to determine factors associated with mortality.
resultsOf the critically ill calves, 34.3% had sepsis and 61.3% died. The final survival model indicated that calves with sepsis (hazard risk [HR]: 1.6; 95% confidence interval [CI]: 1.0-2.5; P = .05), abnormal behavior (HR: 2.3; 95% CI: 1.3-4.0; P = .005), and hypothermia (HR: 0.82; 95% CI: 0.72-0.95; P = .01) had a significantly higher mortality risk. In a second survival model, hypothermia (HR: 0.87; 95% CI: 0.78-0.96; P = .004) and hypoglycemia (HR: 2.2; 95% CI: 1.5-3.3; P < .001) were risk factors for mortality. Decision tree analysis emphasized the importance of behavior, hypochloremia, hypoglycemia, hyperkalemia, and lung ultrasonography for mortality risk. Escherichia coli (30.6%) was most frequently isolated from blood cultures, of which 90.9% were multidrug resistant. Inappropriate use of antimicrobials was frequent for penicillin, amoxicillin, and sulfamethoxazole/trimethoprim, but less for CIA. CONCLUSIONS AND CLINICAL IMPORTANCE: Many critically ill calves have sepsis, which increases mortality risk. Bacteria involved are often resistant to first-intention antimicrobials but less resistant to CIA. The other identified risk factors for mortality can support therapeutic decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.