Evidence map›Paper›PMID 36562154›Full record

Observational studyAddiction (Abingdon, England)2023

Effects of emotional arousal on the neural impact and behavioral efficacy of cigarette graphic warning labels.

Zhenhao Shi, An-Li Wang, Victoria P Fairchild, Catherine A Aronowitz, James H Padley, Kevin G Lynch, James Loughead, Daniel D Langleben

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Addiction (Abingdon, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhenhao ShiDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-5697-2034
An-Li WangDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Victoria P FairchildDepartment of Psychology, Queens College, City University of New York, New York, NY, USA.
Catherine A AronowitzDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
James H PadleyDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Kevin G LynchDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
James LougheadDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Daniel D LanglebenDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
University of Pennsylvania · USIcahn School of Medicine at Mount Sinai · USQueens College, CUNY · US

Funding

Brain and behavioral effects of graphic cigarette warning labelsR01DA036028 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI LANGLEBEN, DANIEL D · 2013 to 2017
$2.9M
Multivariate Modeling of the Neural Mechanisms of Treatment Response in Opioid AddictionK01DA051709 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SHI, ZHENHAO · 2021 to 2025
$916k
Neurobehavioral Study of Warnings for Adolescents at Risk for Nicotine DependenceR00HD084746 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, AN-LI · 2017 to 2019
$747k
NICHD NIH HHS R00 HD084746NIDA NIH HHS K01 DA051709NIDA NIH HHS R01 DA036028
6 · The paper itself

Abstract

BACKGROUND AND

aimsGraphic warning labels (GWLs) on cigarette packs have been adopted by many jurisdictions world-wide. In the United States, the introduction of GWLs has been delayed by claims that their high level of negative emotional arousal unnecessarily infringed upon the tobacco manufacturers' free speech. This study aimed to provide experimental data on the contribution of emotional arousal to GWL efficacy.

designObservational study using long-term naturalistic exposure and functional magnetic resonance imaging.

settingResearch university in Philadelphia, PA, USA.

participantsA total of 168 adult smokers. MEASUREMENTS: For 4 weeks, participants received cigarettes in packs that carried either high-arousal or low-arousal GWLs (n = 84 versus 84). Smoking behavior, quitting-related cognitions and GWL-induced brain response were measured before and after the 4-week exposure. The amygdala and medial prefrontal cortex served as regions of interest.

findingsCompared with the high-arousal group, the low-arousal group smoked fewer cigarettes [log

conclusionsHigh-arousal cigarette graphic warning labels (GWLs) appear to be less efficacious than low-arousal GWLs. The high emotional reaction that high-arousal GWLs elicit wanes over time. Baseline amygdala response negatively predicts efficacy of high-arousal GWLs and positively predicts efficacy of low-arousal GWLs. High emotional arousal may not be required for sustained GWL efficacy.

Indexed as

Tobacco ProductsAdultArousalHumansProduct LabelingSmokingSmoking PreventionTobacco SmokingUnited StatesAmygdalacigarette graphic warning labelsemotional arousalfunctional magnetic resonance imaginglong-term exposuretobacco control policy

Identifiers

PMID36562154
PMCPMC10081532
OpenAlexW4312117928

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.