ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2024
Protocol for a Prospective Observational Study of Revision Palatoplasty Versus Pharyngoplasty for Treatment of Velopharyngeal Insufficiency Following Cleft Palate Repair.
Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Examining Percent Consonants Correct Produced by Preschool Children With and Without Cleft Palate Using the American English Phrase Sample.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- What is the Patient Compliance Rate for Nasopharyngoscopy as Documented in Clinical Reports?The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Inconsistencies in Clinical Reporting of Nasopharyngoscopy for Evaluating Velopharyngeal Closure: A Multisite Study.American journal of speech-language pathology · 2026Article
- An Exploratory Investigation into the Influence of Nasopharyngoscopy Findings on VPI Surgery Selection.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Can Hypernasality be Reliably Rated Using the American English Phrase Sample as a Part of the Cleft Audit Protocol for Speech-Augmented-Americleft Modification (CAPS-A-AM) Protocol?The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Predictors of Poor Speech Outcomes Following Primary Palatoplasty for Patients with Cleft Palate: Do Social Determinants of Health Impact Velopharyngeal Insufficiency?Plastic surgery (Oakville, Ont.) · 2026Article
- How Do Nasopharyngoscopy Ratings of Sustained Speech Differ From Connected Speech?The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Observational
- Examining Factors That Impact Speech Acceptability and Intelligibility in 4- to 7-Year-Old Children With Cleft Palate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Does Successful Surgical Treatment of Velopharyngeal Insufficiency Aid in the Remediation of Compensatory Misarticulation Errors?American journal of speech-language pathology · 2025Article
- Factors That Limit Evaluation of Velopharyngeal Closure During Nasopharyngoscopy.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025Observational
- Velopharyngeal Gap Size During Sustained Vowel Production Correlates With Perceptual Ratings of Hypernasality in Connected Speech.Journal of speech, language, and hearing research : JSLHR · 2024Article
- The Pediatric Neuroradiologist's Practical Guide to Capture and Evaluate Pre- and Postoperative Velopharyngeal Insufficiency.AJNR. American journal of neuroradiology · 2023Article
- Sex Differences in Velopharyngeal Anatomy of 9- and 10-Year-Old Children.Journal of speech, language, and hearing research : JSLHR · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo present the design and methodology for an actively enrolling comparative effectiveness study of revision palatoplasty versus pharyngoplasty for the treatment of velopharyngeal insufficiency (VPI).
designProspective observational multicenter study.
settingTwelve hospitals across the United States and Canada.
participantsIndividuals who are 3-23 years of age with a history of repaired cleft palate and a diagnosis of VPI, with a total enrollment target of 528 participants.
interventionsRevision palatoplasty and pharyngoplasty (either pharyngeal flap or sphincter pharyngoplasty), as selected for each participant by their treatment team. MAIN OUTCOME MEASURE(S): The primary outcome is resolution of hypernasality, defined as the absence of consistent hypernasality as determined by blinded perceptual assessment of a standard speech sample recorded twelve months after surgery. The secondary outcome is incidence of new onset obstructive sleep apnea. Statistical analyses will use propensity score matching to control for demographics, medical history, preoperative severity of hypernasality, and preoperative imaging findings.
resultsStudy recruitment began February 2021. As of September 2022, 148 participants are enrolled, and 78 have undergone VPI surgery. Enrollment is projected to continue into 2025. Collection of postoperative evaluations should be completed by the end of 2026, with dissemination of results soon thereafter.
conclusionsPatients with VPI following cleft palate repair are being actively enrolled at sites across the US and Canada into a prospective observational study evaluating surgical outcomes. This study will be the largest and most comprehensive study of VPI surgery outcomes to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.