ArticleFrontiers in nutrition2022
Causal effects of fatty acids on depression: Mendelian randomization study.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Metabolomic insights into late-life depression: a systematic review.BMC geriatrics · 2025Pooled it
- Evaluating the causal effects of circulating metabolites on major depression disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Mendelian Randomization Identifies Lipidomic Signatures of Depression Risk That Are Partly Reflected in Cortisol-Induced Membrane Remodeling and Modulated by St. John's Wort Extract (Ze 117).International journal of molecular sciences · 2026Article
- Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential.Frontiers in nutrition · 2026Review
- Mendelian Randomisation Analysis of Dietary Exposures and Potential Risks of Anxiety and Depression.Actas espanolas de psiquiatria · 2025Article
- Analysis of Genomic and Transcriptomic Data Revealed Key Genes and Processes in the Development of Major Depressive Disorder.International journal of molecular sciences · 2025Article
- Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders.BMC medicine · 2025Article
- Adrenic acid: A promising biomarker and therapeutic target (Review).International journal of molecular medicine · 2025Review
- Gut microbiota, nutrients, and depression.Frontiers in nutrition · 2025Review
- Abnormalities of lipid metabolism in the progression and treatment of depression.Frontiers in psychiatry · 2025Review
- The role of fatty acids in the emotional well-being of young adults: associations between fatty acid levels and symptoms of depression, anxiety, stress, and sleep disturbances.Postepy psychiatrii neurologii · 2024Article
- Diet supplementation with hemp (The veterinary quarterly · 2024Article
- Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.Nutrients · 2024Article
- The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review.International journal of molecular sciences · 2024Review
- Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation.Frontiers in psychiatry · 2024Article
- Association between plasma polyunsaturated fatty acids and depressive among US adults.Frontiers in nutrition · 2024Article
- Serum Metabolomics Analysis Revealed Metabolic Pathways Related to AECOPD Complicated with Anxiety and Depression.International journal of chronic obstructive pulmonary disease · 2024Observational
- Tea consumption and risk of lung diseases: a two‑sample Mendelian randomization study.BMC pulmonary medicine · 2023Article
- Association of serum oleic acid level with depression in American adults: a cross-sectional study.BMC psychiatry · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Fatty acids (FA) are widely believed to play a role in the pathophysiology of depression. However, the causal relationships between FA and depression remain elusive and warrant further research. We aimed to investigate the potential causal relationship between FA [saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA)] and the risk of depression using Mendelian randomization (MR) analysis. Methods: We conducted a two-sample MR analysis using large-scale European-based genome-wide association studies (GWASs) summary data related to depression ( Results: We found the causal effects for the levels of oleic acid (OA; OR = 1.07, Conclusion: Our study suggests that adrenic acid and EPA are protective against the risk of depression, while OA and ALA are potential risk factors for depression. Nonetheless, the underlying mechanisms that mediate the association between these FAs and depression risk should be investigated in further experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.