Evidence map›Paper›PMID 36562019›Full record

ArticleCJC open2022

Amyloid Deposits in a Functionally Unicuspid Stenotic Aortic Valve.

Anne-Sophie Zenses, Charles Leduc, Stéphanie Béchard, Jessica Forcillo, Zaki El Haffaf, Quoc-Bao Do, Philippe Pibarot, François Tournoux

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anne-Sophie ZensesResearch Centre of the University of Montreal Hospital (CRCHUM), Montreal, Quebec, Canada.
Charles LeducDepartment of Pathology and Cell Biology, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada.
Stéphanie BéchardDepartment of Cardiology, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada.
Jessica ForcilloDepartment of Surgery, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada.
Zaki El HaffafDepartment of Genetic Medicine, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada.
Quoc-Bao DoDepartment of Surgery, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada.
Philippe PibarotResearch Center of the Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada.
François TournouxDepartment of Cardiology, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada.
Centre Hospitalier de l’Université de Montréal · CAUniversité de Montréal · CALung Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloidosis concomitant to aortic stenosis usually occurs with myocardial infiltration by the transthyretin protein. To our knowledge, this is the first report of localized amyloidosis of indeterminate type in a severely calcified and functionally unicuspid aortic valve. Isolated dystrophic valvular amyloidosis is believed to be related to fibrocalcific valve disease. In light of the literature on this topic, the present case raises new hypotheses on pathophysiology and further supports the contributory role of unusual non-tricuspid valve morphology in the development of dystrophic amyloid, likely secondary to altered hemodynamic stress.

Identifiers

PMID36562019
PMCPMC9764129
OpenAlexW4296628535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.